HHV-6A, HHV-6B, and HHV-7 in Febrile Seizures and Status Epilepticus

Leon G Epstein*, John J Millichap

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Febrile seizure is defined as a seizure associated with a febrile illness without a history of afebrile seizure or evidence of an acute central nervous system infection or other insult. Febrile status epilepticus is defined as a febrile seizure with duration greater than 30 minutes. Febrile seizures are the most common seizure type under age 5 years. Febrile status epilepticus is associated with an increased risk of temporal lobe epilepsy with evidence of acute hippocampal injury. Primary HHV-6B infection is a common cause of fever with both febrile seizures and febrile status epilepticus. Reactivated HHV-6B infection following stem cell transplantation has been associated with hippocampal injury and seizures in the context of limbic encephalitis. If the suspected association between HHV-6B infection and temporal lobe epilepsy is proven, then future studies may focus on therapy for HHV-6B infection for the prevention of epilepsy in these children.

Original languageEnglish (US)
Title of host publicationHuman Herpesviruses HHV-6A, HHV-6B, and HHV-7, Third Edition
PublisherElsevier B.V.
Pages69-80
Number of pages12
ISBN (Print)9780444627032
DOIs
StatePublished - Jan 1 2014

Keywords

  • Febrile seizures
  • Human herpesvirus
  • Mesial temporal sclerosis
  • Status epilepticus

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

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    Epstein, L. G., & Millichap, J. J. (2014). HHV-6A, HHV-6B, and HHV-7 in Febrile Seizures and Status Epilepticus. In Human Herpesviruses HHV-6A, HHV-6B, and HHV-7, Third Edition (pp. 69-80). Elsevier B.V.. https://doi.org/10.1016/B978-0-444-62703-2.00004-5