HHV-6A, HHV-6B, and HHV-7 in Febrile Seizures and Status Epilepticus

Leon G. Epstein*, John J. Millichap

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter


Febrile seizure is defined as a seizure associated with a febrile illness without a history of afebrile seizure or evidence of an acute central nervous system infection or other insult. Febrile status epilepticus is defined as a febrile seizure with duration greater than 30 minutes. Febrile seizures are the most common seizure type under age 5 years. Febrile status epilepticus is associated with an increased risk of temporal lobe epilepsy with evidence of acute hippocampal injury. Primary HHV-6B infection is a common cause of fever with both febrile seizures and febrile status epilepticus. Reactivated HHV-6B infection following stem cell transplantation has been associated with hippocampal injury and seizures in the context of limbic encephalitis. If the suspected association between HHV-6B infection and temporal lobe epilepsy is proven, then future studies may focus on therapy for HHV-6B infection for the prevention of epilepsy in these children.

Original languageEnglish (US)
Title of host publicationHuman Herpesviruses HHV-6A, HHV-6B, and HHV-7, Third Edition
PublisherElsevier B.V.
Number of pages12
ISBN (Print)9780444627032
StatePublished - Mar 2014


  • Febrile seizures
  • Human herpesvirus
  • Mesial temporal sclerosis
  • Status epilepticus

ASJC Scopus subject areas

  • Immunology and Microbiology(all)


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