Hierarchy of effects of the MHC and T cell receptor β-chain genes in susceptibility to Theiler's murine encephalomyelitis virus-induced demyelinating disease

C. A. Kappel, M. C. Dal Canto, R. W. Melvold, B. S. Kim*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Intracerebral inoculation of susceptible mice with Theiler's murine encephalomyelitis virus induces a demyelinating disease that is similar to human multiple sclerosis. This murine model for human multiple sclerosis is apparently immune-mediated and the genes involved in the immune response influence the outcome of disease susceptibility as observed with human multiple sclerosis. These genes include the MHC and TCR genes. However, the functional relationships among these genes on the disease susceptibility has not yet been studied. In this study, we demonstrate that the effect of the H- 2(s) genotype from susceptible SJL/J mice overrides the resistant effect of the BALB/c TCR β-chain gene in CXJ recombinant-inbred and BALB.S congenic mice. These results strongly suggest the presence of a hierarchy of genes involved in the immune response in Theiler's murine encephalomyelitis virus- induced demyelinating disease.

Original languageEnglish (US)
Pages (from-to)4322-4326
Number of pages5
JournalJournal of Immunology
Volume147
Issue number12
StatePublished - 1991

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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