HIF-mediated endothelial response during cancer progression

Colin E. Evans, Cristina Branco-Price, Randall S. Johnson*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Tumour growth at primary or secondary extravasation sites leads to localised regions of reduced oxygen tension (hypoxia) in cells both within and surrounding the tumour. Although the angiogenic response of the tumour cell to hypoxia has been widely examined, the effect of hypoxia on other cell types within the tumour microenvironment is less clear. The endothelium is highly responsive to local hypoxia and regulates tumour cell dissemination and ultimately metastatic success through differential regulation of hypoxia-inducible transcription factors (HIFs). The endothelial response to hypoxia particularly mediates key processes that regulate tumour vascu- larisation and cancer progression, including proliferation, migration, adherence, and vascular permeability. This article describes current understanding of the HIF-mediated endothelial response to hypoxia during cancer progression. Endothelial HIF signalling regulates tumour growth and metastasis and is therefore an attractive putative target for treatments that inhibit cancer progression.

Original languageEnglish (US)
Pages (from-to)471-477
Number of pages7
JournalInternational journal of hematology
Volume95
Issue number5
DOIs
StatePublished - May 2012

Keywords

  • Cancer
  • Endothelial
  • Hypoxia
  • Metastasis

ASJC Scopus subject areas

  • Hematology

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