High- and low-voltage activated calcium currents are expressed by neurons cultured from embryonic rat neostriatum

J. Bargas, D. J. Surmeier*, S. T. Kitai

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Current-clamp studies have shown that voltage-dependent Ca currents are present in rat neostriatal neurons. Although these studies have provided evidence for the presence of high-voltage activated Ca channels, it has been unclear whether low-voltage activated channels are also present. Using the whole-cell variant of the patch-clamp technique, we have studied isolated Ca currents in an attempt to answer this question. We have found that both high- and low-voltage activated calcium currents are expressed by neostriatal neurons cultured from embryonic rat brain. These currents are similar in voltage-dependence and pharmacology to those found in other brain neurons.

Original languageEnglish (US)
Pages (from-to)70-74
Number of pages5
JournalBrain Research
Volume541
Issue number1
DOIs
StatePublished - Feb 8 1991

Keywords

  • Calcium
  • Neostriatum
  • Rat
  • Voltage-clamp
  • Whole-cell

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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