High-dose mouse immunoglobulin G administration suppresses Theiler's murine encephalomyelitis virus-induced demyelinating disease

Chang Sung Koh*, Atsushi Inoue, Masashi Yamazaki, B. S. Kim

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

We studied the effect of high-dose mouse IgG on TMEV-induced demyelinating disease (TMEV-IDD). We injected TMEV intracerebrally into susceptible SJL/J mice and induced TMEV-IDD. Mouse IgG were injected intraperitonealy, and clinical course and various immunological indicators were studied. The results show that TMEV-IDD was significantly suppressed both clinically and histologically (P<0.01) when IgG were administered in the effector phase. The delayed type hypersensitivity and T cell proliferative response specific for TMEV were decreased by this treatment. In an ELISPOT assay, the number of TNF-α producing lymphocytes in the spinal cords was low in high-dose IgG treated mice compared with PBS treated control mice. These data suggest that administration of IgG suppresses TMEV-IDD and may be promising treatment to prevent exacerbation of human multiple sclerosis. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)22-28
Number of pages7
JournalJournal of Neuroimmunology
Volume108
Issue number1-2
DOIs
StatePublished - Aug 1 2000

Keywords

  • Demyelination
  • High-dose immunoglobulion therapy
  • Multiple sclerosis
  • Theiler's murine encephalomyelitis virus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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