TY - JOUR
T1 - High-dose tri-alkylator chemotherapy with autologous stem cell rescue in patients with refractory malignancies
AU - Moormeier, Jill A.
AU - Williams, Stephanie F.
AU - Kaminer, Lynne S.
AU - Garner, Miriam
AU - Bitran, Jacob D.
N1 - Copyright:
Copyright 2010 Elsevier B.V., All rights reserved.
PY - 1990/1/3
Y1 - 1990/1/3
N2 - Forty patients with refractory solid tumors or non-Hodgkin's lymphoma were treated with high-dose cyclophosphamide, thiotepa, and carmustine (BCNU), followed by autologous stem cell rescue, in a phase I does escalation study. The dose-limiting toxic effect was delayed drug-induced pulmonary disease, seen in three patients who received 660-750mg of BCNU/m2in combination with cyclophosphamide and thitepa. The early death rate due to toxic effects was 20%; all deaths were attributed to sepsis or respiratory failure. The overall response rate was 63%. The median time to disease progression was 14 weeks. Although this regimen provided effective cytoreduction, its use in heavily pretreated patients with bulky disease is of limited value. [J Natl Cancer Inst 82:29-34,1990]
AB - Forty patients with refractory solid tumors or non-Hodgkin's lymphoma were treated with high-dose cyclophosphamide, thiotepa, and carmustine (BCNU), followed by autologous stem cell rescue, in a phase I does escalation study. The dose-limiting toxic effect was delayed drug-induced pulmonary disease, seen in three patients who received 660-750mg of BCNU/m2in combination with cyclophosphamide and thitepa. The early death rate due to toxic effects was 20%; all deaths were attributed to sepsis or respiratory failure. The overall response rate was 63%. The median time to disease progression was 14 weeks. Although this regimen provided effective cytoreduction, its use in heavily pretreated patients with bulky disease is of limited value. [J Natl Cancer Inst 82:29-34,1990]
UR - http://www.scopus.com/inward/record.url?scp=0025073117&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025073117&partnerID=8YFLogxK
U2 - 10.1093/jnci/82.1.29
DO - 10.1093/jnci/82.1.29
M3 - Article
C2 - 1967148
AN - SCOPUS:0025073117
SN - 0027-8874
VL - 82
SP - 29
EP - 34
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
IS - 1
ER -
