High expression of the receptor tyrosine kinase Tie-1 in acute myeloid leukemia and myelodysplastic syndrome

S. Verstovsek, E. Estey, T. Manshouri, M. Keating, H. Kantarjian, F. J. Giles, M. Albitar*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

The tyrosine kinase receptor Tie-1 has been shown to play a role in angiogenesis and hematopoiesis. We evaluated the level of expression and clinical significance of Tie-1 protein in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). We used western blot analysis to confirm and radioimmunoassay to quantify Tie-1 protein expression in bone marrow samples obtained from untreated patients having AML (66 patients) or MDS (29 patients). Samples obtained from these patients contained significantly higher levels of Tie-1 protein than did control samples (P<0.001). Also, Tie-1 levels were significantly higher in AML patients than MDS patients (P<0.0001). Tie-1 levels did not correlate with complete remission or survival duration in patients having either disease. These data suggest that Tie-1 expression is increased in AML and MDS but that the level of expression does not influence the response to current therapy. The role of Tie-1 overexpression in the reported increased vascularity in the bone marrow of AML and MDS patients requires further investigation.

Original languageEnglish (US)
Pages (from-to)511-516
Number of pages6
JournalLeukemia and Lymphoma
Volume42
Issue number3
DOIs
StatePublished - Jan 1 2001

Keywords

  • AML
  • Angiogenesis
  • MDS
  • Prognosis
  • Tie-1

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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