Abstract
3D photoacoustic computed tomography (3D-PACT) has made great advances in volumetric imaging of biological tissues, with high spatial-temporal resolutions and large penetration depth. The development of 3D-PACT requires high-performance acoustic sensors with a small size, large detection bandwidth, and high sensitivity. In this work, we present a new high-frequency 3D-PACT system that uses a microring resonator (MRR) as the acoustic sensor. The MRR sensor has a size of 80 μm in diameter and was fabricated using the nanoimprint lithography technology. Using the MRR sensor, we have developed a transmission-mode 3D-PACT system that has achieved a detection bandwidth of ~23 MHz, an imaging depth of ~8 mm, a lateral resolution of 114 μm, and an axial resolution of 57 μm. We have demonstrated the 3D PACT’s performance on in vitro phantoms, ex vivo mouse brain, and in vivo mouse ear and tadpole. The MRR-based 3D-PACT system can be a promising tool for structural, functional, and molecular imaging of biological tissues at depths.
| Original language | English (US) |
|---|---|
| Article number | 9891510 |
| Journal | BME Frontiers |
| Volume | 2022 |
| DOIs | |
| State | Published - Jan 2022 |
Funding
This work was sponsored by American Heart Association Collaborative Sciences Award (18CSA34080277); the United States National Institutes of Health (NIH) grants R21EB027981, R21 EB027304, RF1 NS115581 (BRAIN Initiative), R01 NS111039, and R01 EB028143; and Chan Zuck-erberg Initiative Grant (2020-226178), all to J. Yao. NIH grant P41GM135018 was awarded to H. Zhang and C. Sun. This work was performed, in part, at the Center for Nanoscale Materials, a U.S. Department of Energy Office of Science User Facility, and supported by the U.S. Department of Energy, Office of Science, under Contract No. DE-AC02-06CH11357.
ASJC Scopus subject areas
- Biomedical Engineering
- Medicine (miscellaneous)