High-Frequency 3D Photoacoustic Computed Tomography Using an Optical Microring Resonator

Qiangzhou Rong, Youngseop Lee, Yuqi Tang, Tri Vu, Carlos Taboada, Wenhan Zheng, Jun Xia, David A. Czaplewski, Hao F. Zhang, Cheng Sun*, Junjie Yao*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

3D photoacoustic computed tomography (3D-PACT) has made great advances in volumetric imaging of biological tissues, with high spatial-temporal resolutions and large penetration depth. The development of 3D-PACT requires high-performance acoustic sensors with a small size, large detection bandwidth, and high sensitivity. In this work, we present a new high-frequency 3D-PACT system that uses a microring resonator (MRR) as the acoustic sensor. The MRR sensor has a size of 80 μm in diameter and was fabricated using the nanoimprint lithography technology. Using the MRR sensor, we have developed a transmission-mode 3D-PACT system that has achieved a detection bandwidth of ~23 MHz, an imaging depth of ~8 mm, a lateral resolution of 114 μm, and an axial resolution of 57 μm. We have demonstrated the 3D PACT’s performance on in vitro phantoms, ex vivo mouse brain, and in vivo mouse ear and tadpole. The MRR-based 3D-PACT system can be a promising tool for structural, functional, and molecular imaging of biological tissues at depths.

Original languageEnglish (US)
Article number9891510
JournalBME Frontiers
Volume2022
DOIs
StatePublished - Jan 2022

ASJC Scopus subject areas

  • Biomedical Engineering
  • Medicine (miscellaneous)

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