High frequency of MYD88 L265P mutation in primary ocular adnexal marginal zone lymphoma and its clinicopathologic correlation a study from a single institution

Amir Behdad*, Xiao Yi Zhou, Juehua Gao, Kirtee Raparia, David Dittman, Stefan J. Green, Chao Qi, Bryan Betz, Paul Bryar, Qing Chen, Yi Hua Chen

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Scopus citations


Context.-The pathogenesis of primary ocular adnexal marginal zone lymphoma (POAMZL) remains unclear. The reported associations with Chlamydia psittaci infection and MYD88 mutations are highly variable. Objective.-To examine MYD88 L265P mutation in ocular marginal zone lymphomas and correlate with clinicopathologic features and Chlamydia infection. Design.-Presence of MYD88 L265P mutation and Chlamydia infection in lymphoma was analyzed by using sensitive polymerase chain reaction (PCR) methods. Results.-The MYD88 L265P mutation was identified in 8 of 22 POAMZLs (36%), including 2 of 3 cases in which PCR failed to detect clonal IGH gene rearrangement; none of the 4 secondary marginal zone lymphomas were positive. Test results for Chlamydia were negative in all cases. Patients with and without the MYD88 mutation had similar clinicopathologic features. Conclusions.-The MYD88 mutational analysis provides important information in diagnostic workup of POAMZL. The frequent MYD88 mutation suggests a critical role of this aberration in the pathogenesis of POAMZL and may serve as a therapeutic target for patients with progressive disease.

Original languageEnglish (US)
Pages (from-to)483-493
Number of pages11
JournalArchives of Pathology and Laboratory Medicine
Issue number4
StatePublished - Apr 2019


ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

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