TY - JOUR
T1 - High-frequency oscillation and paralysis stabilize surfactant protein-B-deficient infants
AU - King, Erin L.
AU - Shackelford, Gary D.
AU - Hamvas, Aaron
N1 - Funding Information:
This study was supported in part by National Institutes of Health HL/HD54187 (A.H.). An abstract based on these data was presented at the American Thoracic Society International Conference, 16 – 21 May 1997, San Francisco, CA ( Am J Respir Crit Care Med 1997;155:A236 ).
PY - 2001
Y1 - 2001
N2 - Objective: To determine if high-frequency oscillatory ventilation and neuromuscular blockade improve oxygenation and chest radiographic appearance more effectively than high-frequency oscillation alone for surfactant protein-B (SP-B)-deficient infants. Study Design: We reviewed medical records and chest radiographs of five SP-B-deficient infants awaiting lung transplantation. Changes in FiO2 and radiographic scores were analyzed with respect to neuromuscular blockade status. Results: FiO2 consistently increased 0.20 (SD 0.11) during high-frequency ventilation without neuromuscular blockade (p=0.02) and decreased 0.14 (SD 0.11) during high-frequency ventilation with neuromuscular blockade (p=0.05). Chest radiographic appearance, quantified by an expansion/aeration index, consistently deteriorated without neuromuscular blockade (p=0.01) and consistently improved with neuromuscular blockade (p=0.03). Changes in FiO2 correlated with changes in radiograph scores (r=0.7, p < 0.001). Conclusions: High-frequency ventilation with neuromuscular blockade optimizes oxygenation for SP-B-deficient infants. This ventilatory strategy should be considered while awaiting the diagnosis of SP-B deficiency or lung transplantation.
AB - Objective: To determine if high-frequency oscillatory ventilation and neuromuscular blockade improve oxygenation and chest radiographic appearance more effectively than high-frequency oscillation alone for surfactant protein-B (SP-B)-deficient infants. Study Design: We reviewed medical records and chest radiographs of five SP-B-deficient infants awaiting lung transplantation. Changes in FiO2 and radiographic scores were analyzed with respect to neuromuscular blockade status. Results: FiO2 consistently increased 0.20 (SD 0.11) during high-frequency ventilation without neuromuscular blockade (p=0.02) and decreased 0.14 (SD 0.11) during high-frequency ventilation with neuromuscular blockade (p=0.05). Chest radiographic appearance, quantified by an expansion/aeration index, consistently deteriorated without neuromuscular blockade (p=0.01) and consistently improved with neuromuscular blockade (p=0.03). Changes in FiO2 correlated with changes in radiograph scores (r=0.7, p < 0.001). Conclusions: High-frequency ventilation with neuromuscular blockade optimizes oxygenation for SP-B-deficient infants. This ventilatory strategy should be considered while awaiting the diagnosis of SP-B deficiency or lung transplantation.
UR - http://www.scopus.com/inward/record.url?scp=0034779829&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034779829&partnerID=8YFLogxK
U2 - 10.1038/sj.jp.7210555
DO - 10.1038/sj.jp.7210555
M3 - Article
C2 - 11894508
AN - SCOPUS:0034779829
SN - 0743-8346
VL - 21
SP - 421
EP - 425
JO - Journal of Perinatology
JF - Journal of Perinatology
IS - 7
ER -