High-frequency ultrasonic vocalizations index conditioned pharmacological reward in rats

Brian Knutson; Jeffrey Burgdorf; Jaak Panksepp

doi:10.1016/S0031-9384(98)00337-0

High-frequency ultrasonic vocalizations index conditioned pharmacological reward in rats

Brian Knutson^*, Jeffrey Burgdorf, Jaak Panksepp

^*Corresponding author for this work

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

181 Scopus citations

Abstract

We have proposed that short (<0.5 s), high-frequency (~50 kHz) ultrasonic vocalizations ('50-kHz USVs') index a positive affective state in adult rats, because they occur prior to rewarding social interactions (i.e., rough-and-tumble play, sex). To evaluate this hypothesis in the case of nonsocial stimuli, we examined whether rats would make increased 50-kHz USVs in places associated with the administration of rewarding pharmacological compounds [i.e., amphetamine (AMPH) and morphine (MORPH)]. In Experiment 1, rats made a greater percentage of 50-kHz USVs on the AMPH-paired side of a two-compartment chamber than on the vehicle-paired side, even after statistical correction for place preference. In Experiment 2, rats made a higher percentage of 50-kHz USVs on the MORPH-paired side than on the vehicle-paired side, despite nonsignificant place preference. These findings support the hypothesis that 50-kHz USVs mark a positive affective state in rats and introduce a novel and rapid marker of pharmacological reward. Copyright (C) 1999 Elsevier Science Inc.

Original language	English (US)
Pages (from-to)	639-643
Number of pages	5
Journal	Physiology and Behavior
Volume	66
Issue number	4
DOIs	https://doi.org/10.1016/S0031-9384(98)00337-0
State	Published - Jun 1999

Keywords

Amphetamine
Morphine
Rat
Reward
Vocalization

ASJC Scopus subject areas

Experimental and Cognitive Psychology
Behavioral Neuroscience

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10.1016/S0031-9384(98)00337-0

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title = "High-frequency ultrasonic vocalizations index conditioned pharmacological reward in rats",

abstract = "We have proposed that short (<0.5 s), high-frequency (~50 kHz) ultrasonic vocalizations ('50-kHz USVs') index a positive affective state in adult rats, because they occur prior to rewarding social interactions (i.e., rough-and-tumble play, sex). To evaluate this hypothesis in the case of nonsocial stimuli, we examined whether rats would make increased 50-kHz USVs in places associated with the administration of rewarding pharmacological compounds [i.e., amphetamine (AMPH) and morphine (MORPH)]. In Experiment 1, rats made a greater percentage of 50-kHz USVs on the AMPH-paired side of a two-compartment chamber than on the vehicle-paired side, even after statistical correction for place preference. In Experiment 2, rats made a higher percentage of 50-kHz USVs on the MORPH-paired side than on the vehicle-paired side, despite nonsignificant place preference. These findings support the hypothesis that 50-kHz USVs mark a positive affective state in rats and introduce a novel and rapid marker of pharmacological reward. Copyright (C) 1999 Elsevier Science Inc.",

keywords = "Amphetamine, Morphine, Rat, Reward, Vocalization",

author = "Brian Knutson and Jeffrey Burgdorf and Jaak Panksepp",

note = "Funding Information: This work was supported in part by NIMH Postdoctoral Training Grant MH18931 to Brian Knutson, and NIMH Grant HD30387 to Jaak Panksepp. Additional support for was provided by Wright–Patterson Contract #F336016 and ONR Grant NOOO14-96-1-0589. We thank Douglas Pruitt for consultation on design issues and two anonymous reviewers for comments on the manuscript. ",

year = "1999",

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doi = "10.1016/S0031-9384(98)00337-0",

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AU - Knutson, Brian

AU - Burgdorf, Jeffrey

AU - Panksepp, Jaak

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PY - 1999/6

Y1 - 1999/6

N2 - We have proposed that short (<0.5 s), high-frequency (~50 kHz) ultrasonic vocalizations ('50-kHz USVs') index a positive affective state in adult rats, because they occur prior to rewarding social interactions (i.e., rough-and-tumble play, sex). To evaluate this hypothesis in the case of nonsocial stimuli, we examined whether rats would make increased 50-kHz USVs in places associated with the administration of rewarding pharmacological compounds [i.e., amphetamine (AMPH) and morphine (MORPH)]. In Experiment 1, rats made a greater percentage of 50-kHz USVs on the AMPH-paired side of a two-compartment chamber than on the vehicle-paired side, even after statistical correction for place preference. In Experiment 2, rats made a higher percentage of 50-kHz USVs on the MORPH-paired side than on the vehicle-paired side, despite nonsignificant place preference. These findings support the hypothesis that 50-kHz USVs mark a positive affective state in rats and introduce a novel and rapid marker of pharmacological reward. Copyright (C) 1999 Elsevier Science Inc.

AB - We have proposed that short (<0.5 s), high-frequency (~50 kHz) ultrasonic vocalizations ('50-kHz USVs') index a positive affective state in adult rats, because they occur prior to rewarding social interactions (i.e., rough-and-tumble play, sex). To evaluate this hypothesis in the case of nonsocial stimuli, we examined whether rats would make increased 50-kHz USVs in places associated with the administration of rewarding pharmacological compounds [i.e., amphetamine (AMPH) and morphine (MORPH)]. In Experiment 1, rats made a greater percentage of 50-kHz USVs on the AMPH-paired side of a two-compartment chamber than on the vehicle-paired side, even after statistical correction for place preference. In Experiment 2, rats made a higher percentage of 50-kHz USVs on the MORPH-paired side than on the vehicle-paired side, despite nonsignificant place preference. These findings support the hypothesis that 50-kHz USVs mark a positive affective state in rats and introduce a novel and rapid marker of pharmacological reward. Copyright (C) 1999 Elsevier Science Inc.

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KW - Reward

KW - Vocalization

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High-frequency ultrasonic vocalizations index conditioned pharmacological reward in rats

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