High-frequency ultrasonic vocalizations index conditioned pharmacological reward in rats

Brian Knutson; Jeffrey Burgdorf; Jaak Panksepp

doi:10.1016/S0031-9384(98)00337-0

High-frequency ultrasonic vocalizations index conditioned pharmacological reward in rats

Brian Knutson^*, Jeffrey Burgdorf, Jaak Panksepp

^*Corresponding author for this work

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

194 Scopus citations

Abstract

We have proposed that short (<0.5 s), high-frequency (~50 kHz) ultrasonic vocalizations ('50-kHz USVs') index a positive affective state in adult rats, because they occur prior to rewarding social interactions (i.e., rough-and-tumble play, sex). To evaluate this hypothesis in the case of nonsocial stimuli, we examined whether rats would make increased 50-kHz USVs in places associated with the administration of rewarding pharmacological compounds [i.e., amphetamine (AMPH) and morphine (MORPH)]. In Experiment 1, rats made a greater percentage of 50-kHz USVs on the AMPH-paired side of a two-compartment chamber than on the vehicle-paired side, even after statistical correction for place preference. In Experiment 2, rats made a higher percentage of 50-kHz USVs on the MORPH-paired side than on the vehicle-paired side, despite nonsignificant place preference. These findings support the hypothesis that 50-kHz USVs mark a positive affective state in rats and introduce a novel and rapid marker of pharmacological reward. Copyright (C) 1999 Elsevier Science Inc.

Original language	English (US)
Pages (from-to)	639-643
Number of pages	5
Journal	Physiology and Behavior
Volume	66
Issue number	4
DOIs	https://doi.org/10.1016/S0031-9384(98)00337-0
State	Published - Jun 1999

Funding

This work was supported in part by NIMH Postdoctoral Training Grant MH18931 to Brian Knutson, and NIMH Grant HD30387 to Jaak Panksepp. Additional support for was provided by Wright–Patterson Contract #F336016 and ONR Grant NOOO14-96-1-0589. We thank Douglas Pruitt for consultation on design issues and two anonymous reviewers for comments on the manuscript.

Keywords

Amphetamine
Morphine
Rat
Reward
Vocalization

ASJC Scopus subject areas

Experimental and Cognitive Psychology
Behavioral Neuroscience

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10.1016/S0031-9384(98)00337-0

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title = "High-frequency ultrasonic vocalizations index conditioned pharmacological reward in rats",

abstract = "We have proposed that short (<0.5 s), high-frequency (~50 kHz) ultrasonic vocalizations ('50-kHz USVs') index a positive affective state in adult rats, because they occur prior to rewarding social interactions (i.e., rough-and-tumble play, sex). To evaluate this hypothesis in the case of nonsocial stimuli, we examined whether rats would make increased 50-kHz USVs in places associated with the administration of rewarding pharmacological compounds [i.e., amphetamine (AMPH) and morphine (MORPH)]. In Experiment 1, rats made a greater percentage of 50-kHz USVs on the AMPH-paired side of a two-compartment chamber than on the vehicle-paired side, even after statistical correction for place preference. In Experiment 2, rats made a higher percentage of 50-kHz USVs on the MORPH-paired side than on the vehicle-paired side, despite nonsignificant place preference. These findings support the hypothesis that 50-kHz USVs mark a positive affective state in rats and introduce a novel and rapid marker of pharmacological reward. Copyright (C) 1999 Elsevier Science Inc.",

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author = "Brian Knutson and Jeffrey Burgdorf and Jaak Panksepp",

note = "Funding Information: This work was supported in part by NIMH Postdoctoral Training Grant MH18931 to Brian Knutson, and NIMH Grant HD30387 to Jaak Panksepp. Additional support for was provided by Wright–Patterson Contract #F336016 and ONR Grant NOOO14-96-1-0589. We thank Douglas Pruitt for consultation on design issues and two anonymous reviewers for comments on the manuscript. ",

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doi = "10.1016/S0031-9384(98)00337-0",

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AU - Burgdorf, Jeffrey

AU - Panksepp, Jaak

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PY - 1999/6

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N2 - We have proposed that short (<0.5 s), high-frequency (~50 kHz) ultrasonic vocalizations ('50-kHz USVs') index a positive affective state in adult rats, because they occur prior to rewarding social interactions (i.e., rough-and-tumble play, sex). To evaluate this hypothesis in the case of nonsocial stimuli, we examined whether rats would make increased 50-kHz USVs in places associated with the administration of rewarding pharmacological compounds [i.e., amphetamine (AMPH) and morphine (MORPH)]. In Experiment 1, rats made a greater percentage of 50-kHz USVs on the AMPH-paired side of a two-compartment chamber than on the vehicle-paired side, even after statistical correction for place preference. In Experiment 2, rats made a higher percentage of 50-kHz USVs on the MORPH-paired side than on the vehicle-paired side, despite nonsignificant place preference. These findings support the hypothesis that 50-kHz USVs mark a positive affective state in rats and introduce a novel and rapid marker of pharmacological reward. Copyright (C) 1999 Elsevier Science Inc.

AB - We have proposed that short (<0.5 s), high-frequency (~50 kHz) ultrasonic vocalizations ('50-kHz USVs') index a positive affective state in adult rats, because they occur prior to rewarding social interactions (i.e., rough-and-tumble play, sex). To evaluate this hypothesis in the case of nonsocial stimuli, we examined whether rats would make increased 50-kHz USVs in places associated with the administration of rewarding pharmacological compounds [i.e., amphetamine (AMPH) and morphine (MORPH)]. In Experiment 1, rats made a greater percentage of 50-kHz USVs on the AMPH-paired side of a two-compartment chamber than on the vehicle-paired side, even after statistical correction for place preference. In Experiment 2, rats made a higher percentage of 50-kHz USVs on the MORPH-paired side than on the vehicle-paired side, despite nonsignificant place preference. These findings support the hypothesis that 50-kHz USVs mark a positive affective state in rats and introduce a novel and rapid marker of pharmacological reward. Copyright (C) 1999 Elsevier Science Inc.

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KW - Morphine

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KW - Vocalization

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High-frequency ultrasonic vocalizations index conditioned pharmacological reward in rats

Abstract

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Keywords

ASJC Scopus subject areas

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