High-Gamma Activity Is Coupled to Low-Gamma Oscillations in Precentral Cortices and Modulates with Movement and Speech

Jeffrey Z. Nie; Robert D. Flint; Prashanth Prakash; Jason K. Hsieh; Emily M. Mugler; Matthew C. Tate; Joshua M. Rosenow; Marc W. Slutzky

doi:10.1523/ENEURO.0163-23.2023

High-Gamma Activity Is Coupled to Low-Gamma Oscillations in Precentral Cortices and Modulates with Movement and Speech

Jeffrey Z. Nie, Robert D. Flint, Prashanth Prakash, Jason K. Hsieh, Emily M. Mugler, Matthew C. Tate, Joshua M. Rosenow, Marc W. Slutzky^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Planning and executing motor behaviors requires coordinated neural activity among multiple cortical and subcortical regions of the brain. Phase–amplitude coupling between the high-gamma band amplitude and the phase of low frequency oscillations (theta, alpha, beta) has been proposed to reflect neural communication, as has synchronization of low-gamma oscillations. However, coupling between low-gamma and high-gamma bands has not been investigated. Here, we measured phase–amplitude coupling between low-and high-gamma in monkeys performing a reaching task and in humans either performing finger-flexion or word-reading tasks. We found significant coupling between low-gamma phase and high-gamma amplitude in multiple sensorimotor and premotor cortices of both species during all tasks. This coupling modulated with the onset of movement. These findings suggest that interactions between the low and high gamma bands are markers of network dynamics related to movement and speech generation.

Original language	English (US)
Article number	ENEURO.0163-23.2023
Journal	eNeuro
Volume	11
Issue number	2
DOIs	https://doi.org/10.1523/ENEURO.0163-23.2023
State	Published - Feb 2024

Funding

This research was supported in part by National Institutes of Health grants K08NS060223 R01NS094748, R01 NS099210, R01NS112942, and F32- DC-015708 (to E.M.M.); the Dixon Translational Research Grants Initiative at Northwestern Medicine and the Northwestern University Clinical and Translational Sciences Institute (NIH UL1RR025741, UL1-TR-000150, and UL1-TR-001422), Paralyzed Veterans of America Research Grant #2728, Brain Research Foundation (BRF SG 2009-14), Doris Duke Charitable Foundation Clinical Scientist Development Award #2011039, and a Craig H. Neilsen Foundation Fellowship (to R.D.F).

Keywords

ECoG
LFPs
gamma
movement
phase–amplitude coupling
speech

ASJC Scopus subject areas

General Neuroscience

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10.1523/ENEURO.0163-23.2023

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title = "High-Gamma Activity Is Coupled to Low-Gamma Oscillations in Precentral Cortices and Modulates with Movement and Speech",

abstract = "Planning and executing motor behaviors requires coordinated neural activity among multiple cortical and subcortical regions of the brain. Phase–amplitude coupling between the high-gamma band amplitude and the phase of low frequency oscillations (theta, alpha, beta) has been proposed to reflect neural communication, as has synchronization of low-gamma oscillations. However, coupling between low-gamma and high-gamma bands has not been investigated. Here, we measured phase–amplitude coupling between low-and high-gamma in monkeys performing a reaching task and in humans either performing finger-flexion or word-reading tasks. We found significant coupling between low-gamma phase and high-gamma amplitude in multiple sensorimotor and premotor cortices of both species during all tasks. This coupling modulated with the onset of movement. These findings suggest that interactions between the low and high gamma bands are markers of network dynamics related to movement and speech generation.",

keywords = "ECoG, LFPs, gamma, movement, phase–amplitude coupling, speech",

author = "Nie, {Jeffrey Z.} and Flint, {Robert D.} and Prashanth Prakash and Hsieh, {Jason K.} and Mugler, {Emily M.} and Tate, {Matthew C.} and Rosenow, {Joshua M.} and Slutzky, {Marc W.}",

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doi = "10.1523/ENEURO.0163-23.2023",

language = "English (US)",

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AU - Nie, Jeffrey Z.

AU - Flint, Robert D.

AU - Prakash, Prashanth

AU - Hsieh, Jason K.

AU - Mugler, Emily M.

AU - Tate, Matthew C.

AU - Rosenow, Joshua M.

AU - Slutzky, Marc W.

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AB - Planning and executing motor behaviors requires coordinated neural activity among multiple cortical and subcortical regions of the brain. Phase–amplitude coupling between the high-gamma band amplitude and the phase of low frequency oscillations (theta, alpha, beta) has been proposed to reflect neural communication, as has synchronization of low-gamma oscillations. However, coupling between low-gamma and high-gamma bands has not been investigated. Here, we measured phase–amplitude coupling between low-and high-gamma in monkeys performing a reaching task and in humans either performing finger-flexion or word-reading tasks. We found significant coupling between low-gamma phase and high-gamma amplitude in multiple sensorimotor and premotor cortices of both species during all tasks. This coupling modulated with the onset of movement. These findings suggest that interactions between the low and high gamma bands are markers of network dynamics related to movement and speech generation.

KW - ECoG

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High-Gamma Activity Is Coupled to Low-Gamma Oscillations in Precentral Cortices and Modulates with Movement and Speech

Abstract

Funding

Keywords

ASJC Scopus subject areas

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