High-grade prostatic intraepithelial neoplasia of the prostate: The precursor lesion of prostate cancer

Debra L. Zynger*, Ximing Yang

*Corresponding author for this work

Research output: Contribution to journalReview article

20 Scopus citations

Abstract

High-grade intraepithelial neoplasia (HGPIN) is a lesion which is widely believed to be a precursor of prostatic adenocarcinoma. Correct morphologic identification of HGPIN and an understanding of how this diagnosis affects clinical management in the research setting are necessary as HGPIN is a premalignant lesion with many genetic alterations similar to prostate cancer, but is not yet invasive cancer. As such it is critical to differentiate between benign entities, HGPIN, and prostatic adenocarcinoma for experimental design and data interpretation. This review discusses HGPIN, clarifies the terminology used in pathology reports, and describes the clinical and research implications of this entity.

Original languageEnglish (US)
Pages (from-to)327-338
Number of pages12
JournalInternational Journal of Clinical and Experimental Pathology
Volume2
Issue number4
StatePublished - 2009

Keywords

  • HGPIN
  • High-grade prostatic intraepithelial neoplasia
  • Needle biopsy
  • Prostate

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Fingerprint Dive into the research topics of 'High-grade prostatic intraepithelial neoplasia of the prostate: The precursor lesion of prostate cancer'. Together they form a unique fingerprint.

  • Cite this