High intrinsic oxidative stress may underlie selective vulnerability of the hippocampal CA1 region

Xinkun Wang, Ranu Pal, Xue Wen Chen, Nanteetip Limpeanchob, Keshava N. Kumar, Elias K. Michaelis*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

68 Scopus citations

Abstract

Oxidative stress (OS) causes extensive cell death in the CA1 but not the CA3 region of the hippocampus. We found that the CA1 region of hippocampus explants, cultured under normal conditions, had significantly higher superoxide levels and expressed both anti-oxidant genes and genes related to the generation of reactive oxygen species at significantly higher levels than the CA3. These observations were indicative of high intrinsic OS in CA1.

Original languageEnglish (US)
Pages (from-to)120-126
Number of pages7
JournalMolecular Brain Research
Volume140
Issue number1-2
DOIs
StatePublished - Oct 31 2005

Keywords

  • CA1
  • CA3
  • Hippocampus
  • Nrf2
  • Oxidative stress
  • Selective vulnerability

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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