High-level gentamicin resistance in enterococcal bacteremia

Gary A Noskin*, J. R. Warren

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Enterococci are facultatively anaerobic, catalase-negative, gram positive cocci. The bacteria most frequently cause urinary tract infection, and less commonly bacteremia and endocarditis. Enterococcus faecalis is most commonly isolated (80% to 90% of enterococcal bacteremias), followed by Enterococcus faecium. Enterococcal bacteremia is associated with a high mortality (30% to 60%). The organisms are frequently characterized by high-level resistance to the aminoglycoside gentamicin. Attention to laboratory susceptibility results, clinical manifestations, and appropriate antibiotic treatment of high-level gentamicin resistance are crucial for management of these difficult-to-treat infections.

Original languageEnglish (US)
Pages (from-to)615-620
Number of pages6
JournalInfections in Medicine
Volume11
Issue number9
StatePublished - Dec 1 1994

Keywords

  • antibiotic resistance
  • bacteremia
  • Enterococcus
  • gentamicin
  • vancomycin

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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