High levels of an endothelial dysfunction marker (sVCAM-1) are associated with injurious and recurrent falls and mortality over a 5-year interval in an older population

Achille Tchalla*, Gregory A. Wellenius, Sophie Boyer, Thomas G. Travison, Daniel Habtemariam, Margaret Gagnon, Ikechukwu Iloputaife, Farzaneh A. Sorond, Thierry Dantoine, Lewis A. Lipsitz

*Corresponding author for this work

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

We investigated the association between elevated plasma concentrations of circulating soluble Vascular Cell Adhesion Molecule-1 (sVCAM-1) and injurious falls and mortality over a 5-year period. We studied the prospective relationship between levels of circulating adhesion molecules and falls in 680 community-dwelling participants in the MOBILIZE Boston Study. The mean sVCAM-1 (±SD) concentration was 1192 ± 428 ng/mL. Over 5-years of follow-up, 10.2% of participants died. The baseline sVCAM-1 (±SD) concentration was 1434 ± 511 ng/mL in those who died vs. 1162 ± 402 ng/mL in those who survived (P < 0.0001). sVCAM-1 level was associated with recurrent falls (P < 0.01); compared to the lowest quintile, the highest quintile of sVCAM-1 was associated with increased risk of injurious falls [multivariable adjusted Incidence Rate Ratio = 1.9, 95% CI (1.2–2.9), P = 0.009]. On survival analysis, the highest sVCAM-1 quintile was associated with the greatest mortality over 5 years (log-rank test, P < 0.0001). The adjusted hazard ratio was 2.4 [95% CI (2.1–2.7), P = 0.002]. High sVCAM-1 blood concentration was strongly associated with recurrent falls, injurious falls, and mortality in older adults.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalExperimental Gerontology
Volume106
DOIs
StatePublished - Jun 2018

Keywords

  • Adhesion molecule
  • Elderly
  • Endothelial dysfunction
  • Injurious falls
  • Mortality

ASJC Scopus subject areas

  • Biochemistry
  • Aging
  • Molecular Biology
  • Genetics
  • Endocrinology
  • Cell Biology

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