High Relaxivity Gadolinium-Polydopamine Nanoparticles

Zhao Wang, Fabio Carniato, Yijun Xie, Yuran Huang, Yiwen Li, Sha He, Nanzhi Zang, Jeffrey D. Rinehart*, Mauro Botta, Nathan C. Gianneschi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

This study reports the preparation of a series of gadolinium-polydopamine nanoparticles (GdPD-NPs) with tunable metal loadings. GdPD-NPs are analyzed by nuclear magnetic relaxation dispersion and with a 7-tesla (T) magnetic resonance imaging (MRI) scanner. A relaxivity of 75 and 10.3 mM−1 s−1 at 1.4 and 7 T is observed, respectively. Furthermore, superconducting quantum interference device magnetometry is used to study intraparticle magnetic interactions and determine the GdPD-NPs consist of isolated metal ions even at maximum metal loadings. From these data, it is concluded that the observed high relaxivities arise from a high hydration state of the Gd(III) at the particle surface, fast rate of water exchange, and negligible antiferromagnetic coupling between Gd(III) centers throughout the particles. This study highlights design parameters and a robust synthetic approach that aid in the development of this scaffold for T1-weighted, high relaxivity MRI contrast agents.

Original languageEnglish (US)
Article number1701830
JournalSmall
Volume13
Issue number43
DOIs
StatePublished - Nov 20 2017

Keywords

  • MRI
  • antiferromagnetic coupling
  • contrast agent
  • magnetometry
  • polydopamine

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)

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