High Relaxivity Gadolinium-Polydopamine Nanoparticles

Zhao Wang; Fabio Carniato; Yijun Xie; Yuran Huang; Yiwen Li; Sha He; Nanzhi Zang; Jeffrey D. Rinehart; Mauro Botta; Nathan C. Gianneschi

doi:10.1002/smll.201701830

High Relaxivity Gadolinium-Polydopamine Nanoparticles

Zhao Wang, Fabio Carniato, Yijun Xie, Yuran Huang, Yiwen Li, Sha He, Nanzhi Zang, Jeffrey D. Rinehart^*, Mauro Botta, Nathan C. Gianneschi

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

This study reports the preparation of a series of gadolinium-polydopamine nanoparticles (GdPD-NPs) with tunable metal loadings. GdPD-NPs are analyzed by nuclear magnetic relaxation dispersion and with a 7-tesla (T) magnetic resonance imaging (MRI) scanner. A relaxivity of 75 and 10.3 mM⁻¹ s⁻¹ at 1.4 and 7 T is observed, respectively. Furthermore, superconducting quantum interference device magnetometry is used to study intraparticle magnetic interactions and determine the GdPD-NPs consist of isolated metal ions even at maximum metal loadings. From these data, it is concluded that the observed high relaxivities arise from a high hydration state of the Gd(III) at the particle surface, fast rate of water exchange, and negligible antiferromagnetic coupling between Gd(III) centers throughout the particles. This study highlights design parameters and a robust synthetic approach that aid in the development of this scaffold for T₁-weighted, high relaxivity MRI contrast agents.

Original language	English (US)
Article number	1701830
Journal	Small
Volume	13
Issue number	43
DOIs	https://doi.org/10.1002/smll.201701830
State	Published - Nov 20 2017

Keywords

MRI
antiferromagnetic coupling
contrast agent
magnetometry
polydopamine

ASJC Scopus subject areas

Biotechnology
Biomaterials
Chemistry(all)
Materials Science(all)

Access to Document

10.1002/smll.201701830

Cite this

@article{19cc20c2017d429ab534dcc99e5b4981,

title = "High Relaxivity Gadolinium-Polydopamine Nanoparticles",

abstract = "This study reports the preparation of a series of gadolinium-polydopamine nanoparticles (GdPD-NPs) with tunable metal loadings. GdPD-NPs are analyzed by nuclear magnetic relaxation dispersion and with a 7-tesla (T) magnetic resonance imaging (MRI) scanner. A relaxivity of 75 and 10.3 mM−1 s−1 at 1.4 and 7 T is observed, respectively. Furthermore, superconducting quantum interference device magnetometry is used to study intraparticle magnetic interactions and determine the GdPD-NPs consist of isolated metal ions even at maximum metal loadings. From these data, it is concluded that the observed high relaxivities arise from a high hydration state of the Gd(III) at the particle surface, fast rate of water exchange, and negligible antiferromagnetic coupling between Gd(III) centers throughout the particles. This study highlights design parameters and a robust synthetic approach that aid in the development of this scaffold for T1-weighted, high relaxivity MRI contrast agents.",

keywords = "MRI, antiferromagnetic coupling, contrast agent, magnetometry, polydopamine",

author = "Zhao Wang and Fabio Carniato and Yijun Xie and Yuran Huang and Yiwen Li and Sha He and Nanzhi Zang and Rinehart, {Jeffrey D.} and Mauro Botta and Gianneschi, {Nathan C.}",

note = "Funding Information: The authors thank the AFOSR for generous funding through a PECASE to N.C.G. (FA9550-11-1-0105). M.B. acknowledges support of the “Compagnia di San Paolo” (CSP-2012 NANOPROGLY Project). Y.L. acknowledges financial support from the State Key Laboratory of Polymer Materials Engineering, Sichuan University (Grant No. sklpme2016-3-03). This work made use of the Keck-II facility of Northwestern University{\textquoteright}s NUANCE Center, which has received support from the Soft and Hybrid Nanotechnology Experimental (SHyNE) Resource (NSF ECCS-1542205); the MRSEC program (NSF DMR-1121262) at the Materials Research Center; the International Institute for Nanotechnology (IIN); the Keck Foundation; and the State of Illinois, through the IIN. Dr. S.H. acknowledges the support from FISP award (C6007) and Air Force Offfice of Scientific Research (AFOSR) FA9550-15-1-0273. Publisher Copyright: {\textcopyright} 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim",

year = "2017",

month = nov,

day = "20",

doi = "10.1002/smll.201701830",

language = "English (US)",

volume = "13",

journal = "Small",

issn = "1613-6810",

publisher = "Wiley-VCH Verlag",

number = "43",

}

TY - JOUR

T1 - High Relaxivity Gadolinium-Polydopamine Nanoparticles

AU - Wang, Zhao

AU - Carniato, Fabio

AU - Xie, Yijun

AU - Huang, Yuran

AU - Li, Yiwen

AU - He, Sha

AU - Zang, Nanzhi

AU - Rinehart, Jeffrey D.

AU - Botta, Mauro

AU - Gianneschi, Nathan C.

N1 - Funding Information: The authors thank the AFOSR for generous funding through a PECASE to N.C.G. (FA9550-11-1-0105). M.B. acknowledges support of the “Compagnia di San Paolo” (CSP-2012 NANOPROGLY Project). Y.L. acknowledges financial support from the State Key Laboratory of Polymer Materials Engineering, Sichuan University (Grant No. sklpme2016-3-03). This work made use of the Keck-II facility of Northwestern University’s NUANCE Center, which has received support from the Soft and Hybrid Nanotechnology Experimental (SHyNE) Resource (NSF ECCS-1542205); the MRSEC program (NSF DMR-1121262) at the Materials Research Center; the International Institute for Nanotechnology (IIN); the Keck Foundation; and the State of Illinois, through the IIN. Dr. S.H. acknowledges the support from FISP award (C6007) and Air Force Offfice of Scientific Research (AFOSR) FA9550-15-1-0273. Publisher Copyright: © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

PY - 2017/11/20

Y1 - 2017/11/20

N2 - This study reports the preparation of a series of gadolinium-polydopamine nanoparticles (GdPD-NPs) with tunable metal loadings. GdPD-NPs are analyzed by nuclear magnetic relaxation dispersion and with a 7-tesla (T) magnetic resonance imaging (MRI) scanner. A relaxivity of 75 and 10.3 mM−1 s−1 at 1.4 and 7 T is observed, respectively. Furthermore, superconducting quantum interference device magnetometry is used to study intraparticle magnetic interactions and determine the GdPD-NPs consist of isolated metal ions even at maximum metal loadings. From these data, it is concluded that the observed high relaxivities arise from a high hydration state of the Gd(III) at the particle surface, fast rate of water exchange, and negligible antiferromagnetic coupling between Gd(III) centers throughout the particles. This study highlights design parameters and a robust synthetic approach that aid in the development of this scaffold for T1-weighted, high relaxivity MRI contrast agents.

AB - This study reports the preparation of a series of gadolinium-polydopamine nanoparticles (GdPD-NPs) with tunable metal loadings. GdPD-NPs are analyzed by nuclear magnetic relaxation dispersion and with a 7-tesla (T) magnetic resonance imaging (MRI) scanner. A relaxivity of 75 and 10.3 mM−1 s−1 at 1.4 and 7 T is observed, respectively. Furthermore, superconducting quantum interference device magnetometry is used to study intraparticle magnetic interactions and determine the GdPD-NPs consist of isolated metal ions even at maximum metal loadings. From these data, it is concluded that the observed high relaxivities arise from a high hydration state of the Gd(III) at the particle surface, fast rate of water exchange, and negligible antiferromagnetic coupling between Gd(III) centers throughout the particles. This study highlights design parameters and a robust synthetic approach that aid in the development of this scaffold for T1-weighted, high relaxivity MRI contrast agents.

KW - MRI

KW - antiferromagnetic coupling

KW - contrast agent

KW - magnetometry

KW - polydopamine

UR - http://www.scopus.com/inward/record.url?scp=85033688860&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85033688860&partnerID=8YFLogxK

U2 - 10.1002/smll.201701830

DO - 10.1002/smll.201701830

M3 - Article

C2 - 29024478

AN - SCOPUS:85033688860

SN - 1613-6810

VL - 13

JO - Small

JF - Small

IS - 43

M1 - 1701830

ER -

High Relaxivity Gadolinium-Polydopamine Nanoparticles

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this