High-resolution photoacoustic tomography in vivo

Lihong V. Wang; Meng Lin Li; Hao F. Zhang; Konstantin Maslov; George Stoica

High-resolution photoacoustic tomography in vivo

Lihong V. Wang^*, Meng Lin Li, Hao F. Zhang, Konstantin Maslov, George Stoica

^*Corresponding author for this work

Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

7 Scopus citations

Abstract

An in vivo backward-mode photoacoustic microscope was recently developed that employs a high frequency, broadband, large numerical aperture (NA) focused ultrasonic transducer to provide high resolution and high sensitivity. However, out of the focus region, the limited depth of focus deteriorated the image quality significantly. Based on a virtual-detector concept, we devised and implemented a synthetic aperture focusing technique in combination with coherence weighting to overcome this drawback. This technique improved the -6-dB lateral resolution from 50-265 microns to 46-55 microns and increased the SNR by up to 23 dB. In vivo experiments showed that the technique provided a clearer representation of the vascular distribution in the dorsal dermis of a rat.

Original language	English (US)
Title of host publication	2006 3rd IEEE International Symposium on Biomedical Imaging
Subtitle of host publication	From Nano to Macro - Proceedings
Pages	1204-1207
Number of pages	4
Volume	2006
State	Published - Nov 17 2006
Event	2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Arlington, VA, United States Duration: Apr 6 2006 → Apr 9 2006

Other

Other	2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro
Country/Territory	United States
City	Arlington, VA
Period	4/6/06 → 4/9/06

ASJC Scopus subject areas

Engineering(all)

Cite this

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title = "High-resolution photoacoustic tomography in vivo",

abstract = "An in vivo backward-mode photoacoustic microscope was recently developed that employs a high frequency, broadband, large numerical aperture (NA) focused ultrasonic transducer to provide high resolution and high sensitivity. However, out of the focus region, the limited depth of focus deteriorated the image quality significantly. Based on a virtual-detector concept, we devised and implemented a synthetic aperture focusing technique in combination with coherence weighting to overcome this drawback. This technique improved the -6-dB lateral resolution from 50-265 microns to 46-55 microns and increased the SNR by up to 23 dB. In vivo experiments showed that the technique provided a clearer representation of the vascular distribution in the dorsal dermis of a rat.",

author = "Wang, {Lihong V.} and Li, {Meng Lin} and Zhang, {Hao F.} and Konstantin Maslov and George Stoica",

year = "2006",

month = nov,

day = "17",

language = "English (US)",

isbn = "0780395778",

volume = "2006",

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note = "2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro ; Conference date: 06-04-2006 Through 09-04-2006",

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TY - GEN

T1 - High-resolution photoacoustic tomography in vivo

AU - Wang, Lihong V.

AU - Li, Meng Lin

AU - Zhang, Hao F.

AU - Maslov, Konstantin

AU - Stoica, George

PY - 2006/11/17

Y1 - 2006/11/17

N2 - An in vivo backward-mode photoacoustic microscope was recently developed that employs a high frequency, broadband, large numerical aperture (NA) focused ultrasonic transducer to provide high resolution and high sensitivity. However, out of the focus region, the limited depth of focus deteriorated the image quality significantly. Based on a virtual-detector concept, we devised and implemented a synthetic aperture focusing technique in combination with coherence weighting to overcome this drawback. This technique improved the -6-dB lateral resolution from 50-265 microns to 46-55 microns and increased the SNR by up to 23 dB. In vivo experiments showed that the technique provided a clearer representation of the vascular distribution in the dorsal dermis of a rat.

AB - An in vivo backward-mode photoacoustic microscope was recently developed that employs a high frequency, broadband, large numerical aperture (NA) focused ultrasonic transducer to provide high resolution and high sensitivity. However, out of the focus region, the limited depth of focus deteriorated the image quality significantly. Based on a virtual-detector concept, we devised and implemented a synthetic aperture focusing technique in combination with coherence weighting to overcome this drawback. This technique improved the -6-dB lateral resolution from 50-265 microns to 46-55 microns and increased the SNR by up to 23 dB. In vivo experiments showed that the technique provided a clearer representation of the vascular distribution in the dorsal dermis of a rat.

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M3 - Conference contribution

AN - SCOPUS:33750959928

SN - 0780395778

SN - 9780780395770

VL - 2006

SP - 1204

EP - 1207

BT - 2006 3rd IEEE International Symposium on Biomedical Imaging

T2 - 2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro

Y2 - 6 April 2006 through 9 April 2006

ER -

High-resolution photoacoustic tomography in vivo

Abstract

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ASJC Scopus subject areas

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