High-resolution photoacoustic tomography in vivo

Lihong V. Wang*, Meng Lin Li, Hao F. Zhang, Konstantin Maslov, George Stoica

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Scopus citations

Abstract

An in vivo backward-mode photoacoustic microscope was recently developed that employs a high frequency, broadband, large numerical aperture (NA) focused ultrasonic transducer to provide high resolution and high sensitivity. However, out of the focus region, the limited depth of focus deteriorated the image quality significantly. Based on a virtual-detector concept, we devised and implemented a synthetic aperture focusing technique in combination with coherence weighting to overcome this drawback. This technique improved the -6-dB lateral resolution from 50-265 microns to 46-55 microns and increased the SNR by up to 23 dB. In vivo experiments showed that the technique provided a clearer representation of the vascular distribution in the dorsal dermis of a rat.

Original languageEnglish (US)
Title of host publication2006 3rd IEEE International Symposium on Biomedical Imaging
Subtitle of host publicationFrom Nano to Macro - Proceedings
Pages1204-1207
Number of pages4
Volume2006
StatePublished - Nov 17 2006
Event2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Arlington, VA, United States
Duration: Apr 6 2006Apr 9 2006

Other

Other2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro
CountryUnited States
CityArlington, VA
Period4/6/064/9/06

ASJC Scopus subject areas

  • Engineering(all)

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