High-resolution structures of the SARS-CoV-2 2′-O-methyltransferase reveal strategies for structure-based inhibitor design

INIS

• design 66%
• proteins 66%
• methyl transferases 66%
• resolution 33%
• drugs 33%
• therapy 33%
• interfaces 33%
• detection 33%
• crystallography 33%
• x radiation 33%
• diseases 33%
• host 33%
• phosphates 33%
• nucleotides 33%
• messenger-rna 33%
• viruses 33%
• sulfates 33%
• dimers 33%
• ribonucleic acid 33%
• covid-19 33%

Biochemistry, Genetics and Molecular Biology

• SARS Coronavirus 100%
• O-Methyltransferase 66%
• Development 33%
• Conformation 33%
• Host 33%
• Active Site 33%
• Ribonucleotide 33%
• Translation (Protein Synthesis) 33%
• Nucleotide Binding Site 33%
• Flexible Loop 33%
• Betacoronavirus 33%
• Protein 33%
• RNA 33%
• Phosphate 33%
• Virus 33%