TY - JOUR
T1 - High-risk human papillomavirus among HIV-infected women with normal cervical cytology
T2 - A pilot study in Jos, Nigeria
AU - Musa, Jonah
AU - Taiwo, Babafemi
AU - Achenbach, Chad
AU - Olugbenga, Silas
AU - Berzins, Baiba
AU - Sagay, Atiene S.
AU - Idoko, John A.
AU - Kanki, Phyllis J.
AU - Murphy, Robert L.
N1 - Funding Information:
This study was funded through a seed award on completion of a Master of Science in Clinical Investigation training at Northwestern University, Chicago sponsored by the Fogarty Northwestern University AIDS International Training and Research Program (NU-AITRP), grant #-ID43TW007995-01A1. This work was funded in part by the US Department of Health and Human Services, Health Resources and Services Administration [U51HA02522-01-01]. The contents are solely the responsibility of the authors and do not represent the official views of the funding institutions.
PY - 2013/12
Y1 - 2013/12
N2 - Background: Cervical cancer is strongly linked to high-risk human papillomavirus (HR-HPV) and is typically preceded by cytological abnormalities. Less is known in patients with normal cervical cytology (NCC). We investigated the epidemiology of HR-HPV among HIV-infected women with NCC. Methodology: We conducted a cross-sectional study between January and June 2011 among HIV-infected women with NCC at an adult HIV clinic in Jos, Nigeria. Cervical sampling and analysis for HR-HPV by hybrid capture (HC2) with signal amplification was done to determine presence of one or more of the following HR-HPV types: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 or 68. Epidemiologic factors associated with HR-HPV were determined using bivariate statistics and multivariate logistic regression. Results: We evaluated 103 HIV-infected women with Pap cytology. The median age of the women was 32 years (range 21-49). Ninety-seven (94.2 %) had NCC. Cervical samples for HR-HPV DNA testing were available from 89/97 (91.8 %) of the HIV-infected women with NCC. Of the 89 women with cervical samples for HR-HPV DNA testing, 40 (44.9 %) had detectable HR-HPV by HC2 giving a HR-HPV prevalence of 44.9 % (95 % CI 33.9-55.5 %). Age < 30 years was associated with HR-HPV (OR 2.69 [95 % CI 1.05-6.91, p = 0.039]) while history of previous abortion showed an inverse association with HR-HPV (OR 0.33[95 % CI 0.15-0.94, p = 0.039]). Conclusion: The prevalence of HR-HPV is seemingly high among HIV-infected women with NCC in our clinical setting. These data provide support for further investigation of the clinical implications of positive HR-HPV among HIV-infected women with NCC report in cervical cancer prevention programs in Nigeria.
AB - Background: Cervical cancer is strongly linked to high-risk human papillomavirus (HR-HPV) and is typically preceded by cytological abnormalities. Less is known in patients with normal cervical cytology (NCC). We investigated the epidemiology of HR-HPV among HIV-infected women with NCC. Methodology: We conducted a cross-sectional study between January and June 2011 among HIV-infected women with NCC at an adult HIV clinic in Jos, Nigeria. Cervical sampling and analysis for HR-HPV by hybrid capture (HC2) with signal amplification was done to determine presence of one or more of the following HR-HPV types: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 or 68. Epidemiologic factors associated with HR-HPV were determined using bivariate statistics and multivariate logistic regression. Results: We evaluated 103 HIV-infected women with Pap cytology. The median age of the women was 32 years (range 21-49). Ninety-seven (94.2 %) had NCC. Cervical samples for HR-HPV DNA testing were available from 89/97 (91.8 %) of the HIV-infected women with NCC. Of the 89 women with cervical samples for HR-HPV DNA testing, 40 (44.9 %) had detectable HR-HPV by HC2 giving a HR-HPV prevalence of 44.9 % (95 % CI 33.9-55.5 %). Age < 30 years was associated with HR-HPV (OR 2.69 [95 % CI 1.05-6.91, p = 0.039]) while history of previous abortion showed an inverse association with HR-HPV (OR 0.33[95 % CI 0.15-0.94, p = 0.039]). Conclusion: The prevalence of HR-HPV is seemingly high among HIV-infected women with NCC in our clinical setting. These data provide support for further investigation of the clinical implications of positive HR-HPV among HIV-infected women with NCC report in cervical cancer prevention programs in Nigeria.
KW - HIV
KW - Human papillomavirus
KW - Nigeria
KW - Normal cervical cytology
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U2 - 10.1007/s00404-013-2885-x
DO - 10.1007/s00404-013-2885-x
M3 - Article
C2 - 23700253
AN - SCOPUS:84889097902
VL - 288
SP - 1365
EP - 1370
JO - Archives of Gynecology and Obstetrics
JF - Archives of Gynecology and Obstetrics
SN - 0932-0067
IS - 6
ER -