High-risk human papillomavirus among HIV-infected women with normal cervical cytology: A pilot study in Jos, Nigeria

Jonah Musa; Babafemi Taiwo; Chad Achenbach; Silas Olugbenga; Baiba Berzins; Atiene S. Sagay; John A. Idoko; Phyllis J. Kanki; Robert L. Murphy

doi:10.1007/s00404-013-2885-x

High-risk human papillomavirus among HIV-infected women with normal cervical cytology: A pilot study in Jos, Nigeria

Jonah Musa^*, Babafemi Taiwo, Chad Achenbach, Silas Olugbenga, Baiba Berzins, Atiene S. Sagay, John A. Idoko, Phyllis J. Kanki, Robert L. Murphy

^*Corresponding author for this work

Medicine, Infectious Diseases Division

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Background: Cervical cancer is strongly linked to high-risk human papillomavirus (HR-HPV) and is typically preceded by cytological abnormalities. Less is known in patients with normal cervical cytology (NCC). We investigated the epidemiology of HR-HPV among HIV-infected women with NCC. Methodology: We conducted a cross-sectional study between January and June 2011 among HIV-infected women with NCC at an adult HIV clinic in Jos, Nigeria. Cervical sampling and analysis for HR-HPV by hybrid capture (HC2) with signal amplification was done to determine presence of one or more of the following HR-HPV types: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 or 68. Epidemiologic factors associated with HR-HPV were determined using bivariate statistics and multivariate logistic regression. Results: We evaluated 103 HIV-infected women with Pap cytology. The median age of the women was 32 years (range 21-49). Ninety-seven (94.2 %) had NCC. Cervical samples for HR-HPV DNA testing were available from 89/97 (91.8 %) of the HIV-infected women with NCC. Of the 89 women with cervical samples for HR-HPV DNA testing, 40 (44.9 %) had detectable HR-HPV by HC2 giving a HR-HPV prevalence of 44.9 % (95 % CI 33.9-55.5 %). Age < 30 years was associated with HR-HPV (OR 2.69 [95 % CI 1.05-6.91, p = 0.039]) while history of previous abortion showed an inverse association with HR-HPV (OR 0.33[95 % CI 0.15-0.94, p = 0.039]). Conclusion: The prevalence of HR-HPV is seemingly high among HIV-infected women with NCC in our clinical setting. These data provide support for further investigation of the clinical implications of positive HR-HPV among HIV-infected women with NCC report in cervical cancer prevention programs in Nigeria.

Original language	English (US)
Pages (from-to)	1365-1370
Number of pages	6
Journal	Archives of Gynecology and Obstetrics
Volume	288
Issue number	6
DOIs	https://doi.org/10.1007/s00404-013-2885-x
State	Published - Dec 2013

Funding

This study was funded through a seed award on completion of a Master of Science in Clinical Investigation training at Northwestern University, Chicago sponsored by the Fogarty Northwestern University AIDS International Training and Research Program (NU-AITRP), grant #-ID43TW007995-01A1. This work was funded in part by the US Department of Health and Human Services, Health Resources and Services Administration [U51HA02522-01-01]. The contents are solely the responsibility of the authors and do not represent the official views of the funding institutions.

Keywords

HIV
Human papillomavirus
Nigeria
Normal cervical cytology

ASJC Scopus subject areas

Obstetrics and Gynecology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s00404-013-2885-x

Cite this

@article{84e6d9b0b858497eb63bca45f58d96b0,

title = "High-risk human papillomavirus among HIV-infected women with normal cervical cytology: A pilot study in Jos, Nigeria",

abstract = "Background: Cervical cancer is strongly linked to high-risk human papillomavirus (HR-HPV) and is typically preceded by cytological abnormalities. Less is known in patients with normal cervical cytology (NCC). We investigated the epidemiology of HR-HPV among HIV-infected women with NCC. Methodology: We conducted a cross-sectional study between January and June 2011 among HIV-infected women with NCC at an adult HIV clinic in Jos, Nigeria. Cervical sampling and analysis for HR-HPV by hybrid capture (HC2) with signal amplification was done to determine presence of one or more of the following HR-HPV types: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 or 68. Epidemiologic factors associated with HR-HPV were determined using bivariate statistics and multivariate logistic regression. Results: We evaluated 103 HIV-infected women with Pap cytology. The median age of the women was 32 years (range 21-49). Ninety-seven (94.2 %) had NCC. Cervical samples for HR-HPV DNA testing were available from 89/97 (91.8 %) of the HIV-infected women with NCC. Of the 89 women with cervical samples for HR-HPV DNA testing, 40 (44.9 %) had detectable HR-HPV by HC2 giving a HR-HPV prevalence of 44.9 % (95 % CI 33.9-55.5 %). Age < 30 years was associated with HR-HPV (OR 2.69 [95 % CI 1.05-6.91, p = 0.039]) while history of previous abortion showed an inverse association with HR-HPV (OR 0.33[95 % CI 0.15-0.94, p = 0.039]). Conclusion: The prevalence of HR-HPV is seemingly high among HIV-infected women with NCC in our clinical setting. These data provide support for further investigation of the clinical implications of positive HR-HPV among HIV-infected women with NCC report in cervical cancer prevention programs in Nigeria.",

keywords = "HIV, Human papillomavirus, Nigeria, Normal cervical cytology",

author = "Jonah Musa and Babafemi Taiwo and Chad Achenbach and Silas Olugbenga and Baiba Berzins and Sagay, {Atiene S.} and Idoko, {John A.} and Kanki, {Phyllis J.} and Murphy, {Robert L.}",

note = "Funding Information: This study was funded through a seed award on completion of a Master of Science in Clinical Investigation training at Northwestern University, Chicago sponsored by the Fogarty Northwestern University AIDS International Training and Research Program (NU-AITRP), grant #-ID43TW007995-01A1. This work was funded in part by the US Department of Health and Human Services, Health Resources and Services Administration [U51HA02522-01-01]. The contents are solely the responsibility of the authors and do not represent the official views of the funding institutions. ",

year = "2013",

month = dec,

doi = "10.1007/s00404-013-2885-x",

language = "English (US)",

volume = "288",

pages = "1365--1370",

journal = "Archives of Gynecology and Obstetrics",

issn = "0932-0067",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "6",

}

TY - JOUR

T1 - High-risk human papillomavirus among HIV-infected women with normal cervical cytology

T2 - A pilot study in Jos, Nigeria

AU - Musa, Jonah

AU - Taiwo, Babafemi

AU - Achenbach, Chad

AU - Olugbenga, Silas

AU - Berzins, Baiba

AU - Sagay, Atiene S.

AU - Idoko, John A.

AU - Kanki, Phyllis J.

AU - Murphy, Robert L.

N1 - Funding Information: This study was funded through a seed award on completion of a Master of Science in Clinical Investigation training at Northwestern University, Chicago sponsored by the Fogarty Northwestern University AIDS International Training and Research Program (NU-AITRP), grant #-ID43TW007995-01A1. This work was funded in part by the US Department of Health and Human Services, Health Resources and Services Administration [U51HA02522-01-01]. The contents are solely the responsibility of the authors and do not represent the official views of the funding institutions.

PY - 2013/12

Y1 - 2013/12

N2 - Background: Cervical cancer is strongly linked to high-risk human papillomavirus (HR-HPV) and is typically preceded by cytological abnormalities. Less is known in patients with normal cervical cytology (NCC). We investigated the epidemiology of HR-HPV among HIV-infected women with NCC. Methodology: We conducted a cross-sectional study between January and June 2011 among HIV-infected women with NCC at an adult HIV clinic in Jos, Nigeria. Cervical sampling and analysis for HR-HPV by hybrid capture (HC2) with signal amplification was done to determine presence of one or more of the following HR-HPV types: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 or 68. Epidemiologic factors associated with HR-HPV were determined using bivariate statistics and multivariate logistic regression. Results: We evaluated 103 HIV-infected women with Pap cytology. The median age of the women was 32 years (range 21-49). Ninety-seven (94.2 %) had NCC. Cervical samples for HR-HPV DNA testing were available from 89/97 (91.8 %) of the HIV-infected women with NCC. Of the 89 women with cervical samples for HR-HPV DNA testing, 40 (44.9 %) had detectable HR-HPV by HC2 giving a HR-HPV prevalence of 44.9 % (95 % CI 33.9-55.5 %). Age < 30 years was associated with HR-HPV (OR 2.69 [95 % CI 1.05-6.91, p = 0.039]) while history of previous abortion showed an inverse association with HR-HPV (OR 0.33[95 % CI 0.15-0.94, p = 0.039]). Conclusion: The prevalence of HR-HPV is seemingly high among HIV-infected women with NCC in our clinical setting. These data provide support for further investigation of the clinical implications of positive HR-HPV among HIV-infected women with NCC report in cervical cancer prevention programs in Nigeria.

AB - Background: Cervical cancer is strongly linked to high-risk human papillomavirus (HR-HPV) and is typically preceded by cytological abnormalities. Less is known in patients with normal cervical cytology (NCC). We investigated the epidemiology of HR-HPV among HIV-infected women with NCC. Methodology: We conducted a cross-sectional study between January and June 2011 among HIV-infected women with NCC at an adult HIV clinic in Jos, Nigeria. Cervical sampling and analysis for HR-HPV by hybrid capture (HC2) with signal amplification was done to determine presence of one or more of the following HR-HPV types: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 or 68. Epidemiologic factors associated with HR-HPV were determined using bivariate statistics and multivariate logistic regression. Results: We evaluated 103 HIV-infected women with Pap cytology. The median age of the women was 32 years (range 21-49). Ninety-seven (94.2 %) had NCC. Cervical samples for HR-HPV DNA testing were available from 89/97 (91.8 %) of the HIV-infected women with NCC. Of the 89 women with cervical samples for HR-HPV DNA testing, 40 (44.9 %) had detectable HR-HPV by HC2 giving a HR-HPV prevalence of 44.9 % (95 % CI 33.9-55.5 %). Age < 30 years was associated with HR-HPV (OR 2.69 [95 % CI 1.05-6.91, p = 0.039]) while history of previous abortion showed an inverse association with HR-HPV (OR 0.33[95 % CI 0.15-0.94, p = 0.039]). Conclusion: The prevalence of HR-HPV is seemingly high among HIV-infected women with NCC in our clinical setting. These data provide support for further investigation of the clinical implications of positive HR-HPV among HIV-infected women with NCC report in cervical cancer prevention programs in Nigeria.

KW - HIV

KW - Human papillomavirus

KW - Nigeria

KW - Normal cervical cytology

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AN - SCOPUS:84889097902

SN - 0932-0067

VL - 288

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JO - Archives of Gynecology and Obstetrics

JF - Archives of Gynecology and Obstetrics

IS - 6

ER -

High-risk human papillomavirus among HIV-infected women with normal cervical cytology: A pilot study in Jos, Nigeria

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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