High risk of subsequent neoplasms continues with extended follow-up of childhood Hodgkin's disease

Report from the Late Effects Study Group

Smita Bhatia*, Yutaka Yasui, Leslie L. Robison, Jillian M. Birch, Monica K. Bogue, Lisa Diller, Cyndi DeLaat, Franca Fossati-Bellani, Elaine Morgan, Odile Oberlin, Gregory Reaman, Frederick B. Ruymann, Jean Tersak, Anna T. Meadows

*Corresponding author for this work

Research output: Contribution to journalArticle

441 Citations (Scopus)

Abstract

Purpose: We present an update of a previously reported Late Effects Study Group cohort of 1,380 children with Hodgkin's disease (HD) diagnosed between 1955 and 1986 in patients aged 16 years or younger. We describe the pattern and incidence of subsequent neoplasms (SNs) occurring with extended follow-up. Patients and Methods: Median age at diagnosis of HD was 11.7 years (range, 0.3 to 16.9 years) and at last follow-up was 27.8 years. Median length of follow-up was 17.0 years. Results: An additional 103 SNs were ascertained (total SNs = 212). The cohort was at an 18.5-fold increased risk of developing SNs compared with the general population (standardized incidence ratio [SIR], 18.5, 95% CI, 15.6 to 21.7). The cumulative incidence of any second malignancy was 10.6% at 20 years, increasing to 26.3% at 30 years; and of solid malignancies was 7.3% at 20 years, increasing to 23.5% at 30 years. Breast cancer was the most common solid malignancy (SIR, 56.7). Other commonly occurring solid malignancies included thyroid cancer (SIR, 36.4), bone tumors (SIR, 37.1), and colorectal (SIR, 36.4), lung (SIR, 27.3), and gastric cancers (SIR, 63.9). Risk factors for solid tumors included young age at HD and radiation-based therapy. Thirty-two patients developed third neoplasms, with the cumulative incidence approaching 21% at 10 years from diagnosis of second malignancy. Conclusion: Additional follow-up of this large cohort of HD survivors documents an increasing occurrence of known radiation-associated solid tumors, (breast and thyroid cancers), as well as emergence of epithelial neoplasms common in adults, (colon and lung cancers) at a younger age than expected in the general population, necessitating ongoing surveillance of this high risk population.

Original languageEnglish (US)
Pages (from-to)4386-4394
Number of pages9
JournalJournal of Clinical Oncology
Volume21
Issue number23
DOIs
StatePublished - Dec 1 2003

Fingerprint

Hodgkin Disease
Incidence
Neoplasms
Second Primary Neoplasms
Thyroid Neoplasms
Breast Neoplasms
Population
Glandular and Epithelial Neoplasms
Colonic Neoplasms
Stomach Neoplasms
Survivors
Lung Neoplasms
Cohort Studies
Radiotherapy
Radiation
Bone and Bones
Lung

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Bhatia, Smita ; Yasui, Yutaka ; Robison, Leslie L. ; Birch, Jillian M. ; Bogue, Monica K. ; Diller, Lisa ; DeLaat, Cyndi ; Fossati-Bellani, Franca ; Morgan, Elaine ; Oberlin, Odile ; Reaman, Gregory ; Ruymann, Frederick B. ; Tersak, Jean ; Meadows, Anna T. / High risk of subsequent neoplasms continues with extended follow-up of childhood Hodgkin's disease : Report from the Late Effects Study Group. In: Journal of Clinical Oncology. 2003 ; Vol. 21, No. 23. pp. 4386-4394.
@article{55743570736d4a139a743e2c51f12890,
title = "High risk of subsequent neoplasms continues with extended follow-up of childhood Hodgkin's disease: Report from the Late Effects Study Group",
abstract = "Purpose: We present an update of a previously reported Late Effects Study Group cohort of 1,380 children with Hodgkin's disease (HD) diagnosed between 1955 and 1986 in patients aged 16 years or younger. We describe the pattern and incidence of subsequent neoplasms (SNs) occurring with extended follow-up. Patients and Methods: Median age at diagnosis of HD was 11.7 years (range, 0.3 to 16.9 years) and at last follow-up was 27.8 years. Median length of follow-up was 17.0 years. Results: An additional 103 SNs were ascertained (total SNs = 212). The cohort was at an 18.5-fold increased risk of developing SNs compared with the general population (standardized incidence ratio [SIR], 18.5, 95{\%} CI, 15.6 to 21.7). The cumulative incidence of any second malignancy was 10.6{\%} at 20 years, increasing to 26.3{\%} at 30 years; and of solid malignancies was 7.3{\%} at 20 years, increasing to 23.5{\%} at 30 years. Breast cancer was the most common solid malignancy (SIR, 56.7). Other commonly occurring solid malignancies included thyroid cancer (SIR, 36.4), bone tumors (SIR, 37.1), and colorectal (SIR, 36.4), lung (SIR, 27.3), and gastric cancers (SIR, 63.9). Risk factors for solid tumors included young age at HD and radiation-based therapy. Thirty-two patients developed third neoplasms, with the cumulative incidence approaching 21{\%} at 10 years from diagnosis of second malignancy. Conclusion: Additional follow-up of this large cohort of HD survivors documents an increasing occurrence of known radiation-associated solid tumors, (breast and thyroid cancers), as well as emergence of epithelial neoplasms common in adults, (colon and lung cancers) at a younger age than expected in the general population, necessitating ongoing surveillance of this high risk population.",
author = "Smita Bhatia and Yutaka Yasui and Robison, {Leslie L.} and Birch, {Jillian M.} and Bogue, {Monica K.} and Lisa Diller and Cyndi DeLaat and Franca Fossati-Bellani and Elaine Morgan and Odile Oberlin and Gregory Reaman and Ruymann, {Frederick B.} and Jean Tersak and Meadows, {Anna T.}",
year = "2003",
month = "12",
day = "1",
doi = "10.1200/JCO.2003.11.059",
language = "English (US)",
volume = "21",
pages = "4386--4394",
journal = "Journal of Clinical Oncology",
issn = "0732-183X",
publisher = "American Society of Clinical Oncology",
number = "23",

}

Bhatia, S, Yasui, Y, Robison, LL, Birch, JM, Bogue, MK, Diller, L, DeLaat, C, Fossati-Bellani, F, Morgan, E, Oberlin, O, Reaman, G, Ruymann, FB, Tersak, J & Meadows, AT 2003, 'High risk of subsequent neoplasms continues with extended follow-up of childhood Hodgkin's disease: Report from the Late Effects Study Group', Journal of Clinical Oncology, vol. 21, no. 23, pp. 4386-4394. https://doi.org/10.1200/JCO.2003.11.059

High risk of subsequent neoplasms continues with extended follow-up of childhood Hodgkin's disease : Report from the Late Effects Study Group. / Bhatia, Smita; Yasui, Yutaka; Robison, Leslie L.; Birch, Jillian M.; Bogue, Monica K.; Diller, Lisa; DeLaat, Cyndi; Fossati-Bellani, Franca; Morgan, Elaine; Oberlin, Odile; Reaman, Gregory; Ruymann, Frederick B.; Tersak, Jean; Meadows, Anna T.

In: Journal of Clinical Oncology, Vol. 21, No. 23, 01.12.2003, p. 4386-4394.

Research output: Contribution to journalArticle

TY - JOUR

T1 - High risk of subsequent neoplasms continues with extended follow-up of childhood Hodgkin's disease

T2 - Report from the Late Effects Study Group

AU - Bhatia, Smita

AU - Yasui, Yutaka

AU - Robison, Leslie L.

AU - Birch, Jillian M.

AU - Bogue, Monica K.

AU - Diller, Lisa

AU - DeLaat, Cyndi

AU - Fossati-Bellani, Franca

AU - Morgan, Elaine

AU - Oberlin, Odile

AU - Reaman, Gregory

AU - Ruymann, Frederick B.

AU - Tersak, Jean

AU - Meadows, Anna T.

PY - 2003/12/1

Y1 - 2003/12/1

N2 - Purpose: We present an update of a previously reported Late Effects Study Group cohort of 1,380 children with Hodgkin's disease (HD) diagnosed between 1955 and 1986 in patients aged 16 years or younger. We describe the pattern and incidence of subsequent neoplasms (SNs) occurring with extended follow-up. Patients and Methods: Median age at diagnosis of HD was 11.7 years (range, 0.3 to 16.9 years) and at last follow-up was 27.8 years. Median length of follow-up was 17.0 years. Results: An additional 103 SNs were ascertained (total SNs = 212). The cohort was at an 18.5-fold increased risk of developing SNs compared with the general population (standardized incidence ratio [SIR], 18.5, 95% CI, 15.6 to 21.7). The cumulative incidence of any second malignancy was 10.6% at 20 years, increasing to 26.3% at 30 years; and of solid malignancies was 7.3% at 20 years, increasing to 23.5% at 30 years. Breast cancer was the most common solid malignancy (SIR, 56.7). Other commonly occurring solid malignancies included thyroid cancer (SIR, 36.4), bone tumors (SIR, 37.1), and colorectal (SIR, 36.4), lung (SIR, 27.3), and gastric cancers (SIR, 63.9). Risk factors for solid tumors included young age at HD and radiation-based therapy. Thirty-two patients developed third neoplasms, with the cumulative incidence approaching 21% at 10 years from diagnosis of second malignancy. Conclusion: Additional follow-up of this large cohort of HD survivors documents an increasing occurrence of known radiation-associated solid tumors, (breast and thyroid cancers), as well as emergence of epithelial neoplasms common in adults, (colon and lung cancers) at a younger age than expected in the general population, necessitating ongoing surveillance of this high risk population.

AB - Purpose: We present an update of a previously reported Late Effects Study Group cohort of 1,380 children with Hodgkin's disease (HD) diagnosed between 1955 and 1986 in patients aged 16 years or younger. We describe the pattern and incidence of subsequent neoplasms (SNs) occurring with extended follow-up. Patients and Methods: Median age at diagnosis of HD was 11.7 years (range, 0.3 to 16.9 years) and at last follow-up was 27.8 years. Median length of follow-up was 17.0 years. Results: An additional 103 SNs were ascertained (total SNs = 212). The cohort was at an 18.5-fold increased risk of developing SNs compared with the general population (standardized incidence ratio [SIR], 18.5, 95% CI, 15.6 to 21.7). The cumulative incidence of any second malignancy was 10.6% at 20 years, increasing to 26.3% at 30 years; and of solid malignancies was 7.3% at 20 years, increasing to 23.5% at 30 years. Breast cancer was the most common solid malignancy (SIR, 56.7). Other commonly occurring solid malignancies included thyroid cancer (SIR, 36.4), bone tumors (SIR, 37.1), and colorectal (SIR, 36.4), lung (SIR, 27.3), and gastric cancers (SIR, 63.9). Risk factors for solid tumors included young age at HD and radiation-based therapy. Thirty-two patients developed third neoplasms, with the cumulative incidence approaching 21% at 10 years from diagnosis of second malignancy. Conclusion: Additional follow-up of this large cohort of HD survivors documents an increasing occurrence of known radiation-associated solid tumors, (breast and thyroid cancers), as well as emergence of epithelial neoplasms common in adults, (colon and lung cancers) at a younger age than expected in the general population, necessitating ongoing surveillance of this high risk population.

UR - http://www.scopus.com/inward/record.url?scp=0442307703&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0442307703&partnerID=8YFLogxK

U2 - 10.1200/JCO.2003.11.059

DO - 10.1200/JCO.2003.11.059

M3 - Article

VL - 21

SP - 4386

EP - 4394

JO - Journal of Clinical Oncology

JF - Journal of Clinical Oncology

SN - 0732-183X

IS - 23

ER -