High-sensitivity C-reactive protein and parameters of left ventricular dysfunction

Sanjiv J. Shah, Gregory M. Marcus, Ivor L. Gerber, Barry H. McKeown, Joshua C. Vessey, Mark V. Jordan, Michele Huddleston, Elyse Foster, Kanu Chatterjee, Andrew D. Michaels*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

Background: Elevated levels of high-sensitivity C-reactive protein (CRP), an inflammatory marker, have been associated with heart failure. However, it is not known which parameters of left ventricular dysfunction correlate with elevated levels of CRP. Methods and Results: In this cross-sectional study of 98 patients referred for cardiac catheterization, we investigated whether commonly used clinical indices of left ventricular dysfunction correlated with CRP levels. CRP levels were elevated to a greater degree in participants with diabetes mellitus (P =.006) and heart failure (P =.003). Increased CRP levels were associated with increased plasma levels of B-type natriuretic peptide (BNP; P =.0001), decreased left ventricular ejection fraction (LVEF; P =.02), and increased left-ventricular end-diastolic pressure (LVEDP; P =.0005). After multivariable adjustment, LVEDP and CRP were independently associated (P =.046). Conclusion: CRP is increased in patients with heart failure. Of the clinical parameters of left ventricular dysfunction, direct measurement of left ventricular end-diastolic pressure is most closely associated with CRP.

Original languageEnglish (US)
Pages (from-to)61-65
Number of pages5
JournalJournal of Cardiac Failure
Volume12
Issue number1
DOIs
StatePublished - Feb 1 2006

Keywords

  • C-reactive protein
  • Cardiac catheterization
  • Ejection fraction
  • Heart failure
  • Inflammation
  • Left ventricular end-diastolic pressure
  • Natriuretic peptides

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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