High-throughput determination of RNA structures

Eric J. Strobel, Angela M. Yu, Julius B. Lucks*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

65 Scopus citations

Abstract

RNA performs and regulates a diverse range of cellular processes, with new functional roles being uncovered at a rapid pace. Interest is growing in how these functions are linked to RNA structures that form in the complex cellular environment. A growing suite of technologies that use advances in RNA structural probes, high-throughput sequencing and new computational approaches to interrogate RNA structure at unprecedented throughput are beginning to provide insights into RNA structures at new spatial, temporal and cellular scales.

Original languageEnglish (US)
Pages (from-to)615-634
Number of pages20
JournalNature Reviews Genetics
Volume19
Issue number10
DOIs
StatePublished - Oct 1 2018

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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