Abstract
RNA performs and regulates a diverse range of cellular processes, with new functional roles being uncovered at a rapid pace. Interest is growing in how these functions are linked to RNA structures that form in the complex cellular environment. A growing suite of technologies that use advances in RNA structural probes, high-throughput sequencing and new computational approaches to interrogate RNA structure at unprecedented throughput are beginning to provide insights into RNA structures at new spatial, temporal and cellular scales.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 615-634 |
| Number of pages | 20 |
| Journal | Nature Reviews Genetics |
| Volume | 19 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 1 2018 |
Funding
The authors thank A. Coraor, A. Silverman and R. Batey for informative discussions about the chemical kinetic view of reactivities and K. Watters and P. Carlson for assistance with graphics. The authors also thank D. Mathews and C. Khosla for inspiring the connections between the chemical and statistical perspectives of reactivities and V. Gopalan for historical perspectives. They also thank M. Evans for helpful comments on the manuscript. This work was supported by an Arnold and Mabel Beckman Foundation Postdoctoral Fellowship (to E.J.S.), the Tri-Institutional Training Program in Computational Biology and Medicine (via a National Institutes of Health training grant T32GM083937 to A.M.Y.), the National Institute of General Medical Sciences of the National Institutes of Health (grant numbers 1DP2GM110838 and R01GM120582 to J.B.L.) and Searle Funds at the Chicago Community Trust (to J.B.L.). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
ASJC Scopus subject areas
- Molecular Biology
- Genetics
- Genetics(clinical)