High-throughput photocapture approach for reaction discovery

Alison A. Bayly, Benjamin R. McDonald, Milan Mrksich*, Karl A. Scheidt

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Modern organic reaction discovery and development relies on the rapid assessment of large arrays of hypothesis-driven experiments. The time-intensive nature of reaction analysis presents the greatest practical barrier for the execution of this iterative process that underpins the development of new bioactive agents. Toward addressing this critical bottleneck, we report herein a high-throughput analysis (HTA) method of reaction mixtures by photocapture on a 384-spot diazirine-terminated self-assembled monolayer, and selfassembled monolayers for matrix-assisted laser desorption/ionization mass spectrometry (SAMDI-MS) analysis. This analytical platform has been applied to the identification of a single-electron-promoted reductive coupling of acyl azolium species.

Original languageEnglish (US)
Pages (from-to)13261-13266
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number24
StatePublished - Jun 16 2020


  • Azoliums
  • High-throughput analysis
  • Photocapture
  • Self-assembled monolayers

ASJC Scopus subject areas

  • General


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