Higher cerebrospinal fluid MHPG in subjects with dementia of the Alzheimer type: Relationship with cognitive dysfunction

Yvette I. Sheline; Karen Miller; Mark E. Bardgett; John G. Csernansky

doi:10.1097/00019442-199805000-00009

Higher cerebrospinal fluid MHPG in subjects with dementia of the Alzheimer type: Relationship with cognitive dysfunction

Yvette I. Sheline^*, Karen Miller, Mark E. Bardgett, John G. Csernansky

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The authors sought to determine the relationships between cerebrospinal fluid (CSF) levels of three neurotransmitter monoamine metabolites and cognitive function. CSF was collected from subjects with dementia of the Alzheimer's type ([DAT] n = 28) and control subjects (n = 10) for determination of CSF 5-hydroxindole acetic acid (5-HIAA), 3-methoxy-4- hydroxy-phenylglycol (MHPG), and homovanillic acid (HVA) levels. All subjects underwent systematic assessment to determine cognitive function. Subjects with DAT had higher concentrations of CSF MHPG. In the overall sample, cognitive function was inversely correlated with CSF levels of MHPG but not with 5-HIAA or HVA. Within the DAT sample, these correlations did not achieve significance.

Original language	English (US)
Pages (from-to)	155-161
Number of pages	7
Journal	American Journal of Geriatric Psychiatry
Volume	6
Issue number	2
DOIs	https://doi.org/10.1097/00019442-199805000-00009
State	Published - 1998

ASJC Scopus subject areas

Geriatrics and Gerontology
Psychiatry and Mental health

UN SDGs

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10.1097/00019442-199805000-00009

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title = "Higher cerebrospinal fluid MHPG in subjects with dementia of the Alzheimer type: Relationship with cognitive dysfunction",

abstract = "The authors sought to determine the relationships between cerebrospinal fluid (CSF) levels of three neurotransmitter monoamine metabolites and cognitive function. CSF was collected from subjects with dementia of the Alzheimer's type ([DAT] n = 28) and control subjects (n = 10) for determination of CSF 5-hydroxindole acetic acid (5-HIAA), 3-methoxy-4- hydroxy-phenylglycol (MHPG), and homovanillic acid (HVA) levels. All subjects underwent systematic assessment to determine cognitive function. Subjects with DAT had higher concentrations of CSF MHPG. In the overall sample, cognitive function was inversely correlated with CSF levels of MHPG but not with 5-HIAA or HVA. Within the DAT sample, these correlations did not achieve significance.",

author = "Sheline, {Yvette I.} and Karen Miller and Bardgett, {Mark E.} and Csernansky, {John G.}",

note = "Funding Information: This work was supported by grants to the Alzheimer's Disease Research Center (AG05681 and AG03991) and the General Clinical Research Center (RR00036) , both at Washington University Medical Center, in St. Louis, and by grants from the National Institute of Mental Health to Drs. Sheline (K07 MH01370) and Bardgett (MH01109) and by a grant to Dr. Csernansky from the National Institute on Aging (AG11355) . ",

year = "1998",

doi = "10.1097/00019442-199805000-00009",

language = "English (US)",

volume = "6",

pages = "155--161",

journal = "American Journal of Geriatric Psychiatry",

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T1 - Higher cerebrospinal fluid MHPG in subjects with dementia of the Alzheimer type

T2 - Relationship with cognitive dysfunction

AU - Sheline, Yvette I.

AU - Miller, Karen

AU - Bardgett, Mark E.

AU - Csernansky, John G.

N1 - Funding Information: This work was supported by grants to the Alzheimer's Disease Research Center (AG05681 and AG03991) and the General Clinical Research Center (RR00036) , both at Washington University Medical Center, in St. Louis, and by grants from the National Institute of Mental Health to Drs. Sheline (K07 MH01370) and Bardgett (MH01109) and by a grant to Dr. Csernansky from the National Institute on Aging (AG11355) .

PY - 1998

Y1 - 1998

N2 - The authors sought to determine the relationships between cerebrospinal fluid (CSF) levels of three neurotransmitter monoamine metabolites and cognitive function. CSF was collected from subjects with dementia of the Alzheimer's type ([DAT] n = 28) and control subjects (n = 10) for determination of CSF 5-hydroxindole acetic acid (5-HIAA), 3-methoxy-4- hydroxy-phenylglycol (MHPG), and homovanillic acid (HVA) levels. All subjects underwent systematic assessment to determine cognitive function. Subjects with DAT had higher concentrations of CSF MHPG. In the overall sample, cognitive function was inversely correlated with CSF levels of MHPG but not with 5-HIAA or HVA. Within the DAT sample, these correlations did not achieve significance.

AB - The authors sought to determine the relationships between cerebrospinal fluid (CSF) levels of three neurotransmitter monoamine metabolites and cognitive function. CSF was collected from subjects with dementia of the Alzheimer's type ([DAT] n = 28) and control subjects (n = 10) for determination of CSF 5-hydroxindole acetic acid (5-HIAA), 3-methoxy-4- hydroxy-phenylglycol (MHPG), and homovanillic acid (HVA) levels. All subjects underwent systematic assessment to determine cognitive function. Subjects with DAT had higher concentrations of CSF MHPG. In the overall sample, cognitive function was inversely correlated with CSF levels of MHPG but not with 5-HIAA or HVA. Within the DAT sample, these correlations did not achieve significance.

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Higher cerebrospinal fluid MHPG in subjects with dementia of the Alzheimer type: Relationship with cognitive dysfunction

Abstract

ASJC Scopus subject areas

UN SDGs

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