Higher cerebrospinal fluid MHPG in subjects with dementia of the Alzheimer type: Relationship with cognitive dysfunction

Yvette I. Sheline*, Karen Miller, Mark E. Bardgett, John G. Csernansky

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The authors sought to determine the relationships between cerebrospinal fluid (CSF) levels of three neurotransmitter monoamine metabolites and cognitive function. CSF was collected from subjects with dementia of the Alzheimer's type ([DAT] n = 28) and control subjects (n = 10) for determination of CSF 5-hydroxindole acetic acid (5-HIAA), 3-methoxy-4- hydroxy-phenylglycol (MHPG), and homovanillic acid (HVA) levels. All subjects underwent systematic assessment to determine cognitive function. Subjects with DAT had higher concentrations of CSF MHPG. In the overall sample, cognitive function was inversely correlated with CSF levels of MHPG but not with 5-HIAA or HVA. Within the DAT sample, these correlations did not achieve significance.

Original languageEnglish (US)
Pages (from-to)155-161
Number of pages7
JournalAmerican Journal of Geriatric Psychiatry
Volume6
Issue number2
DOIs
StatePublished - Jan 1 1998

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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