Abstract
The authors sought to determine the relationships between cerebrospinal fluid (CSF) levels of three neurotransmitter monoamine metabolites and cognitive function. CSF was collected from subjects with dementia of the Alzheimer's type ([DAT] n = 28) and control subjects (n = 10) for determination of CSF 5-hydroxindole acetic acid (5-HIAA), 3-methoxy-4- hydroxy-phenylglycol (MHPG), and homovanillic acid (HVA) levels. All subjects underwent systematic assessment to determine cognitive function. Subjects with DAT had higher concentrations of CSF MHPG. In the overall sample, cognitive function was inversely correlated with CSF levels of MHPG but not with 5-HIAA or HVA. Within the DAT sample, these correlations did not achieve significance.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 155-161 |
| Number of pages | 7 |
| Journal | American Journal of Geriatric Psychiatry |
| Volume | 6 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1998 |
Funding
This work was supported by grants to the Alzheimer's Disease Research Center (AG05681 and AG03991) and the General Clinical Research Center (RR00036) , both at Washington University Medical Center, in St. Louis, and by grants from the National Institute of Mental Health to Drs. Sheline (K07 MH01370) and Bardgett (MH01109) and by a grant to Dr. Csernansky from the National Institute on Aging (AG11355) .
ASJC Scopus subject areas
- Geriatrics and Gerontology
- Psychiatry and Mental health