Higher Soluble CD163 in Blood Is Associated with Significant Depression Symptoms in Men with HIV

Albert M. Anderson; Fiona Bhondoekhan; Dusica Curanovic; Margery A. Connelly; James D. Otvos; Wendy S. Post; Erin D. Michos; Valentina Stosor; Andrew Levine; Eric Seaberg; Andrea M. Weinstein; James T. Becker

doi:10.1097/QAI.0000000000003063

Higher Soluble CD163 in Blood Is Associated with Significant Depression Symptoms in Men with HIV

Albert M. Anderson^*, Fiona Bhondoekhan, Dusica Curanovic, Margery A. Connelly, James D. Otvos, Wendy S. Post, Erin D. Michos, Valentina Stosor, Andrew Levine, Eric Seaberg, Andrea M. Weinstein, James T. Becker

^*Corresponding author for this work

Medicine, Infectious Diseases Division

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Background:People with HIV (PWH) are more likely to experience depression, a highly morbid disease. More evidence is needed to better understand mechanisms of depression in PWH. We evaluated a panel of blood biomarkers in relation to depression symptoms in the Multicenter AIDS Cohort Study (MACS).Setting:Four sites in the United States.Methods:A cross-sectional analysis was performed within the MACS, a prospective study of cisgender men with and without HIV. Depression was assessed with the Center for Epidemiological Studies-Depression Scale, and six blood biomarkers were measured: GlycA, high sensitivity C-reactive protein (CRP), interleukin-6, CCL2, soluble CD14 (sCD14), and soluble CD163 (sCD163). Using univariable and multivariable logistic regression, the biomarkers and other factors were evaluated in relation to significant depression symptoms (SDS) by Center for Epidemiological Studies-Depression score ≥16.Results:784 men were analyzed; most of whom (63%) were PWH. PWH were more likely to have SDS (32% vs. 21%). In univariable analysis, higher GlycA, CRP, and sCD163 concentrations were associated with SDS. In multivariable analysis, however, only higher sCD163 concentration was associated with SDS (odds ratio = 2.30, 95% CI = 1.11 to 4.76). This relationship was driven by the PWH group (odds ratio = 2.72, 95% CI = 1.12 to 6.58) and remained significant when controlling for antidepressant use. Lack of college education was also associated with SDS.Conclusions:Higher sCD163, a marker of macrophage activation, was significantly associated with significant depression symptoms in the MACS. Further research on this biomarker and macrophage activation in general is warranted to better understand and treat depression in PWH.

Original language	English (US)
Pages (from-to)	325-333
Number of pages	9
Journal	Journal of Acquired Immune Deficiency Syndromes
Volume	91
Issue number	3
DOIs	https://doi.org/10.1097/QAI.0000000000003063
State	Published - Nov 1 2022

Funding

The contents of this publication are solely the responsibility of the authors and do not represent the official views of the National Institutes of Health (NIH). MWCCS (Principal Investigators): Atlanta CRS (Ighovwerha Ofotokun, Anandi Sheth, and Gina Wingood), U01-HL146241; Baltimore CRS (Todd Brown and Joseph Margolick), U01-HL146201; Bronx CRS (Kathryn Anastos and Anjali Sharma), U01-HL146204; Brooklyn CRS (Deborah Gustafson and Tracey Wilson), U01-HL146202; Data Analysis and Coordination Center (Gypsyamber D'Souza, Stephen Gange, and Elizabeth Golub), U01-HL146193; Chicago-Cook County CRS (Mardge Cohen and Audrey French), U01-HL146245; Chicago-Northwestern CRS (Steven Wolinsky), U01-HL146240; Northern California CRS (Bradley Aouizerat, Jennifer Price, and Phyllis Tien), U01-HL146242; Los Angeles CRS (Roger Detels and Matthew Mimiaga), U01-HL146333; Metropolitan Washington CRS (Seble Kassaye and Daniel Merenstein), U01-HL146205; Miami CRS (Maria Alcaide, Margaret Fischl, and Deborah Jones), U01-HL146203; Pittsburgh CRS (Jeremy Martinson and Charles Rinaldo), U01-HL146208; UAB-MS CRS (Mirjam-Colette Kempf, Jodie Dionne-Odom, and Deborah Konkle-Parker), U01-HL146192; UNC CRS (Adaora Adimora), and U01-HL146194. The MWCCS is funded primarily by the National Heart, Lung, and Blood Institute (NHLBI), with additional cofunding from the Eunice Kennedy Shriver National Institute Of Child Health & Human Development (NICHD), National Institute On Aging (NIA), National Institute Of Dental & Craniofacial Research (NIDCR), National Institute Of Allergy And Infectious Diseases (NIAID), National Institute Of Neurological Disorders And Stroke (NINDS), National Institute Of Mental Health (NIMH), National Institute On Drug Abuse (NIDA), National Institute Of Nursing Research (NINR), National Cancer Institute (NCI), National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institute on Deafness and Other Communication Disorders (NIDCD), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), and National Institute on Minority Health and Health Disparities (NIMHD) and in coordination and alignment with the research priorities of the National Institutes of Health, Office of AIDS Research (OAR). MWCCS data collection is also supported by UL1-TR000004 (UCSF CTSA), UL1-TR003098 (JHU ICTR), UL1-TR001881 (UCLA CTSI), P30-AI-050409 (Atlanta CFAR), P30-AI-073961 (Miami CFAR), P30-AI-050410 (UNC CFAR), P30-AI-027767 (UAB CFAR), and P30-MH-116867 (Miami CHARM). The authors also gratefully acknowledge funding from the following sources: K23 MH095679, R21 MH118092, R01 AG062387 (Principal Investigator: A.A.), RO1 HL095129 (Principal Investigator: W.P.), P30AI094189 (Johns Hopkins Center for AIDS Research), and P30AI050409.

Keywords

HIV
antiretroviral therapy
depression
sCD163

ASJC Scopus subject areas

Infectious Diseases
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/QAI.0000000000003063

Cite this

Anderson, A. M., Bhondoekhan, F., Curanovic, D., Connelly, M. A., Otvos, J. D., Post, W. S., Michos, E. D., Stosor, V., Levine, A., Seaberg, E., Weinstein, A. M., & Becker, J. T. (2022). Higher Soluble CD163 in Blood Is Associated with Significant Depression Symptoms in Men with HIV. Journal of Acquired Immune Deficiency Syndromes, 91(3), 325-333. https://doi.org/10.1097/QAI.0000000000003063

@article{0e9c0de4e4b1460db7f4b85f11c716db,

title = "Higher Soluble CD163 in Blood Is Associated with Significant Depression Symptoms in Men with HIV",

abstract = "Background:People with HIV (PWH) are more likely to experience depression, a highly morbid disease. More evidence is needed to better understand mechanisms of depression in PWH. We evaluated a panel of blood biomarkers in relation to depression symptoms in the Multicenter AIDS Cohort Study (MACS).Setting:Four sites in the United States.Methods:A cross-sectional analysis was performed within the MACS, a prospective study of cisgender men with and without HIV. Depression was assessed with the Center for Epidemiological Studies-Depression Scale, and six blood biomarkers were measured: GlycA, high sensitivity C-reactive protein (CRP), interleukin-6, CCL2, soluble CD14 (sCD14), and soluble CD163 (sCD163). Using univariable and multivariable logistic regression, the biomarkers and other factors were evaluated in relation to significant depression symptoms (SDS) by Center for Epidemiological Studies-Depression score ≥16.Results:784 men were analyzed; most of whom (63%) were PWH. PWH were more likely to have SDS (32% vs. 21%). In univariable analysis, higher GlycA, CRP, and sCD163 concentrations were associated with SDS. In multivariable analysis, however, only higher sCD163 concentration was associated with SDS (odds ratio = 2.30, 95% CI = 1.11 to 4.76). This relationship was driven by the PWH group (odds ratio = 2.72, 95% CI = 1.12 to 6.58) and remained significant when controlling for antidepressant use. Lack of college education was also associated with SDS.Conclusions:Higher sCD163, a marker of macrophage activation, was significantly associated with significant depression symptoms in the MACS. Further research on this biomarker and macrophage activation in general is warranted to better understand and treat depression in PWH.",

keywords = "HIV, antiretroviral therapy, depression, sCD163",

author = "Anderson, {Albert M.} and Fiona Bhondoekhan and Dusica Curanovic and Connelly, {Margery A.} and Otvos, {James D.} and Post, {Wendy S.} and Michos, {Erin D.} and Valentina Stosor and Andrew Levine and Eric Seaberg and Weinstein, {Andrea M.} and Becker, {James T.}",

year = "2022",

month = nov,

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doi = "10.1097/QAI.0000000000003063",

language = "English (US)",

volume = "91",

pages = "325--333",

journal = "Journal of Acquired Immune Deficiency Syndromes",

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Anderson, AM, Bhondoekhan, F, Curanovic, D, Connelly, MA, Otvos, JD, Post, WS, Michos, ED, Stosor, V, Levine, A, Seaberg, E, Weinstein, AM & Becker, JT 2022, 'Higher Soluble CD163 in Blood Is Associated with Significant Depression Symptoms in Men with HIV', Journal of Acquired Immune Deficiency Syndromes, vol. 91, no. 3, pp. 325-333. https://doi.org/10.1097/QAI.0000000000003063

TY - JOUR

T1 - Higher Soluble CD163 in Blood Is Associated with Significant Depression Symptoms in Men with HIV

AU - Anderson, Albert M.

AU - Bhondoekhan, Fiona

AU - Curanovic, Dusica

AU - Connelly, Margery A.

AU - Otvos, James D.

AU - Post, Wendy S.

AU - Michos, Erin D.

AU - Stosor, Valentina

AU - Levine, Andrew

AU - Seaberg, Eric

AU - Weinstein, Andrea M.

AU - Becker, James T.

PY - 2022/11/1

Y1 - 2022/11/1

N2 - Background:People with HIV (PWH) are more likely to experience depression, a highly morbid disease. More evidence is needed to better understand mechanisms of depression in PWH. We evaluated a panel of blood biomarkers in relation to depression symptoms in the Multicenter AIDS Cohort Study (MACS).Setting:Four sites in the United States.Methods:A cross-sectional analysis was performed within the MACS, a prospective study of cisgender men with and without HIV. Depression was assessed with the Center for Epidemiological Studies-Depression Scale, and six blood biomarkers were measured: GlycA, high sensitivity C-reactive protein (CRP), interleukin-6, CCL2, soluble CD14 (sCD14), and soluble CD163 (sCD163). Using univariable and multivariable logistic regression, the biomarkers and other factors were evaluated in relation to significant depression symptoms (SDS) by Center for Epidemiological Studies-Depression score ≥16.Results:784 men were analyzed; most of whom (63%) were PWH. PWH were more likely to have SDS (32% vs. 21%). In univariable analysis, higher GlycA, CRP, and sCD163 concentrations were associated with SDS. In multivariable analysis, however, only higher sCD163 concentration was associated with SDS (odds ratio = 2.30, 95% CI = 1.11 to 4.76). This relationship was driven by the PWH group (odds ratio = 2.72, 95% CI = 1.12 to 6.58) and remained significant when controlling for antidepressant use. Lack of college education was also associated with SDS.Conclusions:Higher sCD163, a marker of macrophage activation, was significantly associated with significant depression symptoms in the MACS. Further research on this biomarker and macrophage activation in general is warranted to better understand and treat depression in PWH.

AB - Background:People with HIV (PWH) are more likely to experience depression, a highly morbid disease. More evidence is needed to better understand mechanisms of depression in PWH. We evaluated a panel of blood biomarkers in relation to depression symptoms in the Multicenter AIDS Cohort Study (MACS).Setting:Four sites in the United States.Methods:A cross-sectional analysis was performed within the MACS, a prospective study of cisgender men with and without HIV. Depression was assessed with the Center for Epidemiological Studies-Depression Scale, and six blood biomarkers were measured: GlycA, high sensitivity C-reactive protein (CRP), interleukin-6, CCL2, soluble CD14 (sCD14), and soluble CD163 (sCD163). Using univariable and multivariable logistic regression, the biomarkers and other factors were evaluated in relation to significant depression symptoms (SDS) by Center for Epidemiological Studies-Depression score ≥16.Results:784 men were analyzed; most of whom (63%) were PWH. PWH were more likely to have SDS (32% vs. 21%). In univariable analysis, higher GlycA, CRP, and sCD163 concentrations were associated with SDS. In multivariable analysis, however, only higher sCD163 concentration was associated with SDS (odds ratio = 2.30, 95% CI = 1.11 to 4.76). This relationship was driven by the PWH group (odds ratio = 2.72, 95% CI = 1.12 to 6.58) and remained significant when controlling for antidepressant use. Lack of college education was also associated with SDS.Conclusions:Higher sCD163, a marker of macrophage activation, was significantly associated with significant depression symptoms in the MACS. Further research on this biomarker and macrophage activation in general is warranted to better understand and treat depression in PWH.

KW - HIV

KW - antiretroviral therapy

KW - depression

KW - sCD163

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AN - SCOPUS:85140274000

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Higher Soluble CD163 in Blood Is Associated with Significant Depression Symptoms in Men with HIV

Abstract

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UN SDGs

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