Highly accelerated cardiac MRI using iterative SENSE reconstruction: initial clinical experience

Bradley D. Allen*, Maria Carr, Marcos P.F. Botelho, Amir Ali Rahsepar, Michael Markl, Michael O. Zenge, Michaela Schmidt, Mariappan S. Nadar, Bruce Spottiswoode, Jeremy D Collins, James Carr

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


To evaluate the qualitative and quantitative performance of an accelerated cardiovascular MRI (CMR) protocol that features iterative SENSE reconstruction and spatio-temporal L1-regularization (IS SENSE). Twenty consecutively recruited patients and 9 healthy volunteers were included. 2D steady state free precession cine images including 3-chamber, 4-chamber, and short axis slices were acquired using standard parallel imaging (GRAPPA, acceleration factor = 2), spatio-temporal undersampled TSENSE (acceleration factor = 4), and IS SENSE techniques (acceleration factor = 4). Acquisition times, quantitative cardiac functional parameters, wall motion abnormalities (WMA), and qualitative performance (scale: 1-poor to 5-excellent for overall image quality, noise, and artifact) were compared. Breath-hold times for IS SENSE (3.0 ± 0.6 s) and TSENSE (3.3 ± 0.6) were both reduced relative to GRAPPA (8.4 ± 1.7 s, p < 0.001). No difference in quantitative cardiac function was present between the three techniques (p = 0.89 for ejection fraction). GRAPPA and IS SENSE had similar image quality (4.7 ± 0.4 vs. 4.5 ± 0.6, p = 0.09) while, both techniques were superior to TSENSE (quality: 4.1 ± 0.7, p < 0.001). GRAPPA WMA agreement with IS SENSE was good (κ > 0.60, p < 0.001), while agreement with TSENSE was poor (κ < 0.40, p < 0.001). IS SENSE is a viable clinical CMR acceleration approach to reduce acquisition times while maintaining satisfactory qualitative and quantitative performance.

Original languageEnglish (US)
Pages (from-to)955-963
Number of pages9
JournalInternational Journal of Cardiovascular Imaging
Issue number6
StatePublished - Jun 1 2016


  • Accelerated MRI
  • Cardiac gated imaging techniques
  • Cardiac magnetic resonance imaging
  • Ventricular function

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Highly accelerated cardiac MRI using iterative SENSE reconstruction: initial clinical experience'. Together they form a unique fingerprint.

Cite this