Abstract
A Brønsted acid-catalyzed Prins-type cyclization sequence to construct spirooxindole pyrans in high yields and excellent diastereoselectivity has been developed. The combination of a β-hydroxy dioxinone fragment and isatin dimethyl acetal generate oxa-spirooxindoles efficiently. These compounds are diversifiable scaffolds that tap into the rich chemistry of dioxinones.
Original language | English (US) |
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Pages (from-to) | 3086-3089 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 13 |
Issue number | 12 |
DOIs | |
State | Published - Jun 17 2011 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry