TLX1 and TLX3 are two closely-related homeobox transcriptional repressors frequently misexpressed and translocated in T cell acute lymphoblastic leukemia (T-ALL). In this issue of Cancer Cell, Dadi et al. provide new insights into how these factors are recruited by ETS-1 to the TCRα enhancer and actively repress differentiation.
|Original language||English (US)|
|Number of pages||3|
|State||Published - Apr 17 2012|
ASJC Scopus subject areas
- Cancer Research
- Cell Biology