Hijacking T Cell Differentiation: New Insights in TLX Function in T-ALL

Bryan King, Panagiotis Ntziachristos, Iannis Aifantis*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

1 Scopus citations

Abstract

TLX1 and TLX3 are two closely-related homeobox transcriptional repressors frequently misexpressed and translocated in T cell acute lymphoblastic leukemia (T-ALL). In this issue of Cancer Cell, Dadi et al. provide new insights into how these factors are recruited by ETS-1 to the TCRα enhancer and actively repress differentiation.

Original languageEnglish (US)
Pages (from-to)453-455
Number of pages3
JournalCancer Cell
Volume21
Issue number4
DOIs
StatePublished - Apr 17 2012

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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