Hijacking T Cell Differentiation: New Insights in TLX Function in T-ALL

Bryan King; Panagiotis Ntziachristos; Iannis Aifantis

doi:10.1016/j.ccr.2012.03.026

Hijacking T Cell Differentiation: New Insights in TLX Function in T-ALL

Bryan King, Panagiotis Ntziachristos, Iannis Aifantis^*

^*Corresponding author for this work

Biochemistry and Molecular Genetics

Research output: Contribution to journal › Short survey › peer-review

1 Scopus citations

Abstract

TLX1 and TLX3 are two closely-related homeobox transcriptional repressors frequently misexpressed and translocated in T cell acute lymphoblastic leukemia (T-ALL). In this issue of Cancer Cell, Dadi et al. provide new insights into how these factors are recruited by ETS-1 to the TCRα enhancer and actively repress differentiation.

Original language	English (US)
Pages (from-to)	453-455
Number of pages	3
Journal	Cancer cell
Volume	21
Issue number	4
DOIs	https://doi.org/10.1016/j.ccr.2012.03.026
State	Published - Apr 17 2012

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ccr.2012.03.026

Cite this

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title = "Hijacking T Cell Differentiation: New Insights in TLX Function in T-ALL",

abstract = "TLX1 and TLX3 are two closely-related homeobox transcriptional repressors frequently misexpressed and translocated in T cell acute lymphoblastic leukemia (T-ALL). In this issue of Cancer Cell, Dadi et al. provide new insights into how these factors are recruited by ETS-1 to the TCRα enhancer and actively repress differentiation.",

author = "Bryan King and Panagiotis Ntziachristos and Iannis Aifantis",

year = "2012",

month = apr,

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T2 - New Insights in TLX Function in T-ALL

AU - King, Bryan

AU - Ntziachristos, Panagiotis

AU - Aifantis, Iannis

PY - 2012/4/17

Y1 - 2012/4/17

N2 - TLX1 and TLX3 are two closely-related homeobox transcriptional repressors frequently misexpressed and translocated in T cell acute lymphoblastic leukemia (T-ALL). In this issue of Cancer Cell, Dadi et al. provide new insights into how these factors are recruited by ETS-1 to the TCRα enhancer and actively repress differentiation.

AB - TLX1 and TLX3 are two closely-related homeobox transcriptional repressors frequently misexpressed and translocated in T cell acute lymphoblastic leukemia (T-ALL). In this issue of Cancer Cell, Dadi et al. provide new insights into how these factors are recruited by ETS-1 to the TCRα enhancer and actively repress differentiation.

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U2 - 10.1016/j.ccr.2012.03.026

DO - 10.1016/j.ccr.2012.03.026

M3 - Short survey

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JO - Cancer cell

JF - Cancer cell

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ER -

Hijacking T Cell Differentiation: New Insights in TLX Function in T-ALL

Abstract

ASJC Scopus subject areas

UN SDGs

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