Hippocampal activity during memory disruption of passive avoidance by electroconvulsive shock

Aryeh Routtenberg*, Eugene B. Zechmeister, Chrismarie Benton

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Hippocampal activity was monitored during 1-trial passive avoidance learning of foot shock (FS) disrupted by electroconvulsive shock (ECS). Animals receiving FS showed synchronized activity concurrent with aversive responses and took significantly longer than FS-ECS subjects to descend from a platform 24 hrs. after experimental treatment. FS-ECS animals showed overt tonic-clonic seizures and hippocampal epileptiform activity followed by typical post-ictal behavioral and electrographic depression. On the retention trials, FS animals exhibited desynchronization concomitant with freezing behavior. No obvious difference in hippocampal activity between FS and FS-ECS animals was found that could be related to differences in retention; rather, such activity appeared to be related to momentary behavior patterns. It was suggested that hippocampus may function in initial stages of stimulas processing, resisting contamination of past experience.

Original languageEnglish (US)
Pages (from-to)909-918
Number of pages10
JournalLife Sciences
Volume9
Issue number16 PART 1
DOIs
StatePublished - Aug 15 1970

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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