Hippocampal activity was monitored during 1-trial passive avoidance learning of foot shock (FS) disrupted by electroconvulsive shock (ECS). Animals receiving FS showed synchronized activity concurrent with aversive responses and took significantly longer than FS-ECS subjects to descend from a platform 24 hrs. after experimental treatment. FS-ECS animals showed overt tonic-clonic seizures and hippocampal epileptiform activity followed by typical post-ictal behavioral and electrographic depression. On the retention trials, FS animals exhibited desynchronization concomitant with freezing behavior. No obvious difference in hippocampal activity between FS and FS-ECS animals was found that could be related to differences in retention; rather, such activity appeared to be related to momentary behavior patterns. It was suggested that hippocampus may function in initial stages of stimulas processing, resisting contamination of past experience.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology, Toxicology and Pharmaceutics(all)