Hippocampal atrophy in recurrent major depression

Yvette I. Sheline*, Po W. Wang, Mokhtar H. Gado, John G. Csernansky, Michael W. Vannier

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1595 Scopus citations


Hippocampal volumes of subjects with a history of major depressive episodes but currently in remission and with no known medical comorbidity were compared to matched normal controls by using volumetric magnetic resonance images. Subjects with a history of major depression had significantly smaller left and right hippocampal volumes with no differences in total cerebral volumes. The degree of hippocampal volume reduction correlated with total duration of major depression. In addition, large (diameter ≥ 4.5 mm)-hippocampal low signal foci (LSF) were found within the hippocampus, and their number also correlated with the total number of days depressed. These results suggest that depression is associated with hippocampal atrophy, perhaps due to a progressive process mediated by glucocorticoid neurotoxicity.

Original languageEnglish (US)
Pages (from-to)3908-3913
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number9
StatePublished - Apr 30 1996

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Hippocampal atrophy in recurrent major depression'. Together they form a unique fingerprint.

Cite this