Hippocampal size anomalies in a community-based cohort with childhood-onset epilepsy

A. T. Berg, H. R. Pardoe, R. K. Fulbright, S. U. Schuele, G. D. Jackson

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


OBJECTIVES:: Epidemiologic evidence suggests the natural history of refractory mesial temporal lobe epilepsy is complicated, yet little is known about the hippocampus from the nontertiary center perspective. Methods: In a community-based cohort, individuals with nonsyndromic focal epilepsy with onset <16 years and controls had research MRI scans. Hippocampal (HC) volumes were manually measured, corrected for total brain volume, and converted to Z scores (ZHC) based on the controls'values. Volumes in cases and controls were compared. Results: Average volumes were not significantly different in cases with unknown cause (n = 117) relative to controls (n = 63). The group with structural and other conditions (n = 23) had significantly smaller volumes. Asymmetry (larger/smaller HC) did not vary among the 3 groups. Hippocampal variances were significantly larger in each epilepsy group relative to controls. In the unknown cause group, 25 (21%) had extreme values: 15 (13%) with ZHC >1.96; 10 (9%) with ZHC <-1.96. By contrast, 2/63 (3%) controls had extreme values (p = 0.001). Within the unknown cause group, temporal lobe epilepsy (TLE) cases were more likely to have extreme hippocampal volumes than non-TLE (31% vs 15%, p = 0.03). Extreme volumes were generally interpreted as normal visually. These anomalies were not associated with seizure remission or pharmacoresistance. Conclusions: Classic mesial TLE with hippocampal sclerosis is an uncommon finding in the general population. Volume anomalies, both large and small, are often bilateral. The significance of these findings is unclear; however, speculations regarding preexisting hippocampal pathology (e.g., dysplasia) as a factor in TLE and other neocortical epilepsies have been made by others.

Original languageEnglish (US)
Pages (from-to)1415-1421
Number of pages7
Issue number16
StatePublished - Apr 19 2011

ASJC Scopus subject areas

  • Clinical Neurology


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