Hippocampal subfield surface deformity in nonsemantic primary progressive aphasia

Adam Christensen; Kathryn Alpert; Emily Rogalski; Derin Cobia; Julia Rao; Mirza Faisal Beg; Sandra Weintraub; M. Marsel Mesulam; Lei Wang

doi:10.1016/j.dadm.2014.11.013

Hippocampal subfield surface deformity in nonsemantic primary progressive aphasia

Adam Christensen^*, Kathryn Alpert, Emily Rogalski, Derin Cobia, Julia Rao, Mirza Faisal Beg, Sandra Weintraub, M. Marsel Mesulam, Lei Wang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Background: Alzheimer neuropathology is found in almost half of patients with nonsemantic primary progressive aphasia (PPA). This study examined hippocampal abnormalities in PPA to determine similarities to those described in amnestic Alzheimer disease. Methods: In 37 PPA patients and 32 healthy controls, we generated hippocampal subfield surface maps from structural magnetic resonance images and administered a face memory test. We analyzed group and hemisphere differences for surface shape measures and their relationship with test scores and APOE genotype. Results: The hippocampus in PPA showed inward deformity (CA1 and subiculum subfields) and outward deformity (CA2-4 + dentate gyrus subfield) and smaller left than right volumes. Memory performance was related to hippocampal shape abnormalities in PPA patients, but not controls, even in the absence of memory impairments. Conclusions: Hippocampal deformity in PPA is related to memory test scores. This may reflect a combination of intrinsic degenerative phenomena with transsynaptic or Wallerian effects of neocortical neuronal loss.

Original language	English (US)
Pages (from-to)	14-23
Number of pages	10
Journal	Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume	1
Issue number	1
DOIs	https://doi.org/10.1016/j.dadm.2014.11.013
State	Published - 2015

Keywords

Alzheimer's disease (AD)
Frontotemporal dementia
Lobar degeneration
Memory
Multiatlas mapping
Neuroanatomy
Primary progressive aphasia (PPA)
Structural magnetic resonance imaging (MRI)

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.dadm.2014.11.013

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@article{982966cfb0b0444898381ea4d93414d1,

title = "Hippocampal subfield surface deformity in nonsemantic primary progressive aphasia",

abstract = "Background: Alzheimer neuropathology is found in almost half of patients with nonsemantic primary progressive aphasia (PPA). This study examined hippocampal abnormalities in PPA to determine similarities to those described in amnestic Alzheimer disease. Methods: In 37 PPA patients and 32 healthy controls, we generated hippocampal subfield surface maps from structural magnetic resonance images and administered a face memory test. We analyzed group and hemisphere differences for surface shape measures and their relationship with test scores and APOE genotype. Results: The hippocampus in PPA showed inward deformity (CA1 and subiculum subfields) and outward deformity (CA2-4 + dentate gyrus subfield) and smaller left than right volumes. Memory performance was related to hippocampal shape abnormalities in PPA patients, but not controls, even in the absence of memory impairments. Conclusions: Hippocampal deformity in PPA is related to memory test scores. This may reflect a combination of intrinsic degenerative phenomena with transsynaptic or Wallerian effects of neocortical neuronal loss.",

keywords = "Alzheimer's disease (AD), Frontotemporal dementia, Lobar degeneration, Memory, Multiatlas mapping, Neuroanatomy, Primary progressive aphasia (PPA), Structural magnetic resonance imaging (MRI)",

author = "Adam Christensen and Kathryn Alpert and Emily Rogalski and Derin Cobia and Julia Rao and Beg, {Mirza Faisal} and Sandra Weintraub and Mesulam, {M. Marsel} and Lei Wang",

note = "Funding Information: This study was supported in part by a grant titled Language in PPA ( DC008552 ) from the National Institute on Deafness and Other Communication Disorders , the National Institute of Neurological Disorders and Stroke (NINDS; R01 NS075075 ) and by the Alzheimer Disease Core Center grant from the National Institute on Aging ( AG13854 ) both at the Northwestern University Cognitive Neurology and Alzheimer's Disease Center, and NIH grants R01 NR014182 , P50 AG05681 , P01 AG03991 , P01 AG026276 . The Northwestern PPA Research Program and Cognitive Neurology and Alzheimer's Disease Center at Northwestern University's Feinberg School of Medicine conducted clinical and cognitive examinations and collected neuroimaging data for all PPA and control subjects. Some atlas images were provided from work that was in part funded by the Alzheimer's Association : “A Harmonized Protocol for Hippocampal Volumetry: an EADC-ADNI Effort”, grant n. IIRG -10-174022 ; project PI Giovanni B Frisoni, IRCCS Fatebenefratelli, Brescia, Italy; co-PI Clifford R. Jack, Mayo Clinic, Rochester, MN. We would like to thank Ashley Chong and Hande Ozergin for discussions on manual editing procedures. Publisher Copyright: {\textcopyright} 2015 The Authors.",

year = "2015",

doi = "10.1016/j.dadm.2014.11.013",

language = "English (US)",

volume = "1",

pages = "14--23",

journal = "Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring",

issn = "2352-8729",

publisher = "Elsevier BV",

number = "1",

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TY - JOUR

T1 - Hippocampal subfield surface deformity in nonsemantic primary progressive aphasia

AU - Christensen, Adam

AU - Alpert, Kathryn

AU - Rogalski, Emily

AU - Cobia, Derin

AU - Rao, Julia

AU - Beg, Mirza Faisal

AU - Weintraub, Sandra

AU - Mesulam, M. Marsel

AU - Wang, Lei

N1 - Funding Information: This study was supported in part by a grant titled Language in PPA ( DC008552 ) from the National Institute on Deafness and Other Communication Disorders , the National Institute of Neurological Disorders and Stroke (NINDS; R01 NS075075 ) and by the Alzheimer Disease Core Center grant from the National Institute on Aging ( AG13854 ) both at the Northwestern University Cognitive Neurology and Alzheimer's Disease Center, and NIH grants R01 NR014182 , P50 AG05681 , P01 AG03991 , P01 AG026276 . The Northwestern PPA Research Program and Cognitive Neurology and Alzheimer's Disease Center at Northwestern University's Feinberg School of Medicine conducted clinical and cognitive examinations and collected neuroimaging data for all PPA and control subjects. Some atlas images were provided from work that was in part funded by the Alzheimer's Association : “A Harmonized Protocol for Hippocampal Volumetry: an EADC-ADNI Effort”, grant n. IIRG -10-174022 ; project PI Giovanni B Frisoni, IRCCS Fatebenefratelli, Brescia, Italy; co-PI Clifford R. Jack, Mayo Clinic, Rochester, MN. We would like to thank Ashley Chong and Hande Ozergin for discussions on manual editing procedures. Publisher Copyright: © 2015 The Authors.

PY - 2015

Y1 - 2015

N2 - Background: Alzheimer neuropathology is found in almost half of patients with nonsemantic primary progressive aphasia (PPA). This study examined hippocampal abnormalities in PPA to determine similarities to those described in amnestic Alzheimer disease. Methods: In 37 PPA patients and 32 healthy controls, we generated hippocampal subfield surface maps from structural magnetic resonance images and administered a face memory test. We analyzed group and hemisphere differences for surface shape measures and their relationship with test scores and APOE genotype. Results: The hippocampus in PPA showed inward deformity (CA1 and subiculum subfields) and outward deformity (CA2-4 + dentate gyrus subfield) and smaller left than right volumes. Memory performance was related to hippocampal shape abnormalities in PPA patients, but not controls, even in the absence of memory impairments. Conclusions: Hippocampal deformity in PPA is related to memory test scores. This may reflect a combination of intrinsic degenerative phenomena with transsynaptic or Wallerian effects of neocortical neuronal loss.

AB - Background: Alzheimer neuropathology is found in almost half of patients with nonsemantic primary progressive aphasia (PPA). This study examined hippocampal abnormalities in PPA to determine similarities to those described in amnestic Alzheimer disease. Methods: In 37 PPA patients and 32 healthy controls, we generated hippocampal subfield surface maps from structural magnetic resonance images and administered a face memory test. We analyzed group and hemisphere differences for surface shape measures and their relationship with test scores and APOE genotype. Results: The hippocampus in PPA showed inward deformity (CA1 and subiculum subfields) and outward deformity (CA2-4 + dentate gyrus subfield) and smaller left than right volumes. Memory performance was related to hippocampal shape abnormalities in PPA patients, but not controls, even in the absence of memory impairments. Conclusions: Hippocampal deformity in PPA is related to memory test scores. This may reflect a combination of intrinsic degenerative phenomena with transsynaptic or Wallerian effects of neocortical neuronal loss.

KW - Alzheimer's disease (AD)

KW - Frontotemporal dementia

KW - Lobar degeneration

KW - Memory

KW - Multiatlas mapping

KW - Neuroanatomy

KW - Primary progressive aphasia (PPA)

KW - Structural magnetic resonance imaging (MRI)

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U2 - 10.1016/j.dadm.2014.11.013

DO - 10.1016/j.dadm.2014.11.013

M3 - Article

C2 - 25893207

AN - SCOPUS:84938695204

SN - 2352-8729

VL - 1

SP - 14

EP - 23

JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

IS - 1

ER -

Hippocampal subfield surface deformity in nonsemantic primary progressive aphasia

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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