Hippocampectomy disrupts trace eye-blink conditioning in rabbits

James R. Moyer, Richard A. Deyo, John F Disterhoft*

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The role of the hippocampus (HFC) in trace eye-blink conditioning was evaluated using a 100-ms tone conditioned stimulus (CS), a 300- or 500-ms trace interval, and a 150-ms air puff unconditioned stimulus (UCS). Rabbits received complete hippocampectomy (dorsal & ventral), sham lesions, or neocortical lesions. Hippocampectomy produced differential effects in relation to the trace interval used. With a 300-ms trace interval, HPC-lesioned Ss showed profound resistance to extinction after acquisition. With a 500-ms trace interval, HPC-lesioned Ss did not learn the task (only 22% conditioned responses (CRs) after 25 sessions, whereas controls showed >80% after 10 sessions), and on the few trials in which a CR occurred, most were "nonadaptive" short-latency CRs (i.e., they started during or just after the CS and always terminated prior to UCS onset). The authors conclude that the HPC encodes a temporal relationship between CS and UCS, and when the trace interval is long enough (e.g., 500 ms), that the HPC is necessary for associative learning of the conditioned eye-blink response.

Original languageEnglish (US)
Pages (from-to)523-532
Number of pages10
JournalBehavioral Neuroscience
Volume129
Issue number4
DOIs
StatePublished - Jan 1 2015

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Rabbits
Reaction Time
Hippocampus
Air
Learning
Conditioning (Psychology)
Psychological Extinction

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Moyer, James R. ; Deyo, Richard A. ; Disterhoft, John F. / Hippocampectomy disrupts trace eye-blink conditioning in rabbits. In: Behavioral Neuroscience. 2015 ; Vol. 129, No. 4. pp. 523-532.
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Hippocampectomy disrupts trace eye-blink conditioning in rabbits. / Moyer, James R.; Deyo, Richard A.; Disterhoft, John F.

In: Behavioral Neuroscience, Vol. 129, No. 4, 01.01.2015, p. 523-532.

Research output: Contribution to journalArticle

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