Hippocampus sparing volumetric modulated arc therapy in patients with loco-regionally advanced oropharyngeal cancer

Seung Won Seol, Brian HeeEun Lee, Timothy L. Sita, Jay Ram Devineni, Timothy Joseph Kruser, Sean Sachdev, Michelle S Gentile, Irene Helenowski, Bharat B. Mittal*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

This study aimed to assess the incidental radiation exposure of the hippocampus (HC) in locoregionally-advanced oropharyngeal cancer patients undergoing volumetric modulated arc therapy and the feasibility of HC-sparing plan optimization. The initial plans were generated without dose-volume constraints to the HC and were compared with the HC-sparing plans. The incidental Dmean_median doses to the bilateral, ipsilateral and contralateral HC were 2.9, 3.1, and 2.5 Gy in the initial plans and 1.4, 1.6, and 1.3 Gy with HC-sparing. It was feasible to reduce the HC dose with HC-sparing plan optimization without compromising target coverage and/or dose constraints to other OARs.

Original languageEnglish (US)
Pages (from-to)71-75
Number of pages5
JournalPhysics and Imaging in Radiation Oncology
Volume24
DOIs
StatePublished - Oct 2022

Keywords

  • Hippocampus
  • Hippocampus-sparing
  • IMRT
  • Oropharyngeal
  • Plan optimization

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging

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