Hippocampus sparing volumetric modulated arc therapy in patients with loco-regionally advanced oropharyngeal cancer

Seung Won Seol; Brian HeeEun Lee; Timothy L. Sita; Jay Ram Devineni; Timothy Joseph Kruser; Sean Sachdev; Michelle S Gentile; Irene Helenowski; Bharat B. Mittal

doi:10.1016/j.phro.2022.09.008

Hippocampus sparing volumetric modulated arc therapy in patients with loco-regionally advanced oropharyngeal cancer

Seung Won Seol, Brian HeeEun Lee, Timothy L. Sita, Jay Ram Devineni, Timothy Joseph Kruser, Sean Sachdev, Michelle S Gentile, Irene Helenowski, Bharat B. Mittal^*

^*Corresponding author for this work

Radiation Oncology

Research output: Contribution to journal › Article › peer-review

Abstract

This study aimed to assess the incidental radiation exposure of the hippocampus (HC) in locoregionally-advanced oropharyngeal cancer patients undergoing volumetric modulated arc therapy and the feasibility of HC-sparing plan optimization. The initial plans were generated without dose-volume constraints to the HC and were compared with the HC-sparing plans. The incidental D_mean_median doses to the bilateral, ipsilateral and contralateral HC were 2.9, 3.1, and 2.5 Gy in the initial plans and 1.4, 1.6, and 1.3 Gy with HC-sparing. It was feasible to reduce the HC dose with HC-sparing plan optimization without compromising target coverage and/or dose constraints to other OARs.

Original language	English (US)
Pages (from-to)	71-75
Number of pages	5
Journal	Physics and Imaging in Radiation Oncology
Volume	24
DOIs	https://doi.org/10.1016/j.phro.2022.09.008
State	Published - Oct 2022

Keywords

Hippocampus
Hippocampus-sparing
IMRT
Oropharyngeal
Plan optimization

ASJC Scopus subject areas

Radiation
Oncology
Radiology Nuclear Medicine and imaging

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.phro.2022.09.008

Cite this

@article{2ac6208b08c24685b572441617d54245,

title = "Hippocampus sparing volumetric modulated arc therapy in patients with loco-regionally advanced oropharyngeal cancer",

abstract = "This study aimed to assess the incidental radiation exposure of the hippocampus (HC) in locoregionally-advanced oropharyngeal cancer patients undergoing volumetric modulated arc therapy and the feasibility of HC-sparing plan optimization. The initial plans were generated without dose-volume constraints to the HC and were compared with the HC-sparing plans. The incidental Dmean_median doses to the bilateral, ipsilateral and contralateral HC were 2.9, 3.1, and 2.5 Gy in the initial plans and 1.4, 1.6, and 1.3 Gy with HC-sparing. It was feasible to reduce the HC dose with HC-sparing plan optimization without compromising target coverage and/or dose constraints to other OARs.",

keywords = "Hippocampus, Hippocampus-sparing, IMRT, Oropharyngeal, Plan optimization",

author = "Seol, {Seung Won} and Lee, {Brian HeeEun} and Sita, {Timothy L.} and Devineni, {Jay Ram} and Kruser, {Timothy Joseph} and Sean Sachdev and Gentile, {Michelle S} and Irene Helenowski and Mittal, {Bharat B.}",

note = "Funding Information: Not applicable. Publisher Copyright: {\textcopyright} 2022 The Author(s)",

year = "2022",

month = oct,

doi = "10.1016/j.phro.2022.09.008",

language = "English (US)",

volume = "24",

pages = "71--75",

journal = "Physics and Imaging in Radiation Oncology",

issn = "2405-6316",

publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Hippocampus sparing volumetric modulated arc therapy in patients with loco-regionally advanced oropharyngeal cancer

AU - Seol, Seung Won

AU - Lee, Brian HeeEun

AU - Sita, Timothy L.

AU - Devineni, Jay Ram

AU - Kruser, Timothy Joseph

AU - Sachdev, Sean

AU - Gentile, Michelle S

AU - Helenowski, Irene

AU - Mittal, Bharat B.

PY - 2022/10

Y1 - 2022/10

N2 - This study aimed to assess the incidental radiation exposure of the hippocampus (HC) in locoregionally-advanced oropharyngeal cancer patients undergoing volumetric modulated arc therapy and the feasibility of HC-sparing plan optimization. The initial plans were generated without dose-volume constraints to the HC and were compared with the HC-sparing plans. The incidental Dmean_median doses to the bilateral, ipsilateral and contralateral HC were 2.9, 3.1, and 2.5 Gy in the initial plans and 1.4, 1.6, and 1.3 Gy with HC-sparing. It was feasible to reduce the HC dose with HC-sparing plan optimization without compromising target coverage and/or dose constraints to other OARs.

AB - This study aimed to assess the incidental radiation exposure of the hippocampus (HC) in locoregionally-advanced oropharyngeal cancer patients undergoing volumetric modulated arc therapy and the feasibility of HC-sparing plan optimization. The initial plans were generated without dose-volume constraints to the HC and were compared with the HC-sparing plans. The incidental Dmean_median doses to the bilateral, ipsilateral and contralateral HC were 2.9, 3.1, and 2.5 Gy in the initial plans and 1.4, 1.6, and 1.3 Gy with HC-sparing. It was feasible to reduce the HC dose with HC-sparing plan optimization without compromising target coverage and/or dose constraints to other OARs.

KW - Hippocampus

KW - Hippocampus-sparing

KW - IMRT

KW - Oropharyngeal

KW - Plan optimization

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UR - http://www.scopus.com/inward/citedby.url?scp=85139365431&partnerID=8YFLogxK

U2 - 10.1016/j.phro.2022.09.008

DO - 10.1016/j.phro.2022.09.008

M3 - Article

C2 - 36217428

AN - SCOPUS:85139365431

VL - 24

SP - 71

EP - 75

JO - Physics and Imaging in Radiation Oncology

JF - Physics and Imaging in Radiation Oncology

SN - 2405-6316

ER -

Hippocampus sparing volumetric modulated arc therapy in patients with loco-regionally advanced oropharyngeal cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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