Histamine inhibition of neutrophil lysosomal enzyme release: An H 2 histamine receptor response

William W. Busse*, Jeffrey Sosman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Human polymorphonuclear leukocytes treated with cytochalasin B release the lysosomal enzyme beta glucuronidase during contact with serum-activated zymosan particles. Histamine increases intracellular cyclic adenosine monophosphate and inhibits release of this enzyme. The H2 antihistamine metiamide blocks the histamine inhibition of lysosomal enzyme release and the increase in the intracellular adenosine 3,5′-monophosphate of granulocytes. Chlorpheniramine, an HI antihistamine, did not block the histamine inhibition of granulocyte lysosomal enzyme release.

Original languageEnglish (US)
Pages (from-to)735-737
Number of pages3
Issue number4266
StatePublished - Dec 1 1976

ASJC Scopus subject areas

  • Medicine(all)
  • General


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