Histamine inhibition of neutrophil lysosomal enzyme release: An H2 histamine receptor response

W. W. Busse, J. Sosman

Research output: Contribution to journalArticlepeer-review

67 Scopus citations

Abstract

Human polymorphonuclear leukocytes treated with cytochalasin B release the lysosomal enzyme beta glucuronidase during contact with serum activated zymosan particles. Histamine increases intracellular cyclic adenosine monophosphate and inhibits release of this enzyme. The H2 antihistamine metiamide blocks the histamine inhibition of lysosomal enzyme release and the increase in the intracellular adenosine 3,5' monophosphate of granulocytes. Chlorpheniramine, an H1 antihistamine, did not block the histamine inhibition of granulocyte lysosomal enzyme release.

Original languageEnglish (US)
Pages (from-to)737-738
Number of pages2
JournalScience
Volume194
Issue number4266
DOIs
StatePublished - Jan 1 1976

ASJC Scopus subject areas

  • General

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