Histamine N-methyltransferase Thr105Ile polymorphism is associated with Parkinson's disease

Vinko Palada, Janoš Terzić, Joseph Mazzulli, Grace Bwala, Johann Hagenah, Borut Peterlin, Albert Y. Hung, Christine Klein, Dimitri Krainc*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Histamine is a central neurotransmitter degraded by histamine-N-methyltransferase (HNMT). Several abnormalities in the histaminergic system were found in patients with Parkinson's disease (PD), thus we tested the possible association of a Thr105Ile functional polymorphism in HNMT with PD. A total of 913 patients with PD and 958 controls were genotyped using a TaqMan RT-PCR Genotyping Assay (Foster City, California, USA). Lower frequency of HNMT Ile105 allele that is associated with decreased enzymatic activity was found in patients compared with controls (χ2 = 11.65; p = 0.0006). We performed meta-analysis to confirm the association of Thr105Ile functional polymorphism with PD. Our results indicate that lower HNMT activity plays a role in the pathogenesis of PD.

Original languageEnglish (US)
Pages (from-to)836.e1-836.e3
JournalNeurobiology of Aging
Issue number4
StatePublished - Apr 2012


  • Association studies in genetics
  • HNMT
  • Histamine
  • Parkinson's disease
  • Parkinsonism

ASJC Scopus subject areas

  • General Neuroscience
  • Aging
  • Developmental Biology
  • Clinical Neurology
  • Geriatrics and Gerontology


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