Histamine N-methyltransferase Thr105Ile polymorphism is associated with Parkinson's disease

Vinko Palada, Janoš Terzić, Joseph Mazzulli, Grace Bwala, Johann Hagenah, Borut Peterlin, Albert Y. Hung, Christine Klein, Dimitri Krainc*

*Corresponding author for this work

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Histamine is a central neurotransmitter degraded by histamine-N-methyltransferase (HNMT). Several abnormalities in the histaminergic system were found in patients with Parkinson's disease (PD), thus we tested the possible association of a Thr105Ile functional polymorphism in HNMT with PD. A total of 913 patients with PD and 958 controls were genotyped using a TaqMan RT-PCR Genotyping Assay (Foster City, California, USA). Lower frequency of HNMT Ile105 allele that is associated with decreased enzymatic activity was found in patients compared with controls (χ2 = 11.65; p = 0.0006). We performed meta-analysis to confirm the association of Thr105Ile functional polymorphism with PD. Our results indicate that lower HNMT activity plays a role in the pathogenesis of PD.

Original languageEnglish (US)
Pages (from-to)836.e1-836.e3
JournalNeurobiology of Aging
Volume33
Issue number4
DOIs
StatePublished - Jan 1 2012

Fingerprint

Histamine N-Methyltransferase
Parkinson Disease
Histamine
Neurotransmitter Agents
Meta-Analysis
Alleles
Polymerase Chain Reaction

Keywords

  • Association studies in genetics
  • HNMT
  • Histamine
  • Parkinson's disease
  • Parkinsonism

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Palada, Vinko ; Terzić, Janoš ; Mazzulli, Joseph ; Bwala, Grace ; Hagenah, Johann ; Peterlin, Borut ; Hung, Albert Y. ; Klein, Christine ; Krainc, Dimitri. / Histamine N-methyltransferase Thr105Ile polymorphism is associated with Parkinson's disease. In: Neurobiology of Aging. 2012 ; Vol. 33, No. 4. pp. 836.e1-836.e3.
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Histamine N-methyltransferase Thr105Ile polymorphism is associated with Parkinson's disease. / Palada, Vinko; Terzić, Janoš; Mazzulli, Joseph; Bwala, Grace; Hagenah, Johann; Peterlin, Borut; Hung, Albert Y.; Klein, Christine; Krainc, Dimitri.

In: Neurobiology of Aging, Vol. 33, No. 4, 01.01.2012, p. 836.e1-836.e3.

Research output: Contribution to journalArticle

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AU - Palada, Vinko

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