Histiocytosis X: Flow Cytometric DNA-Content and Immunohistochemical and Ultrastructural Analysis

N. S. Goldberg, K. Bauer, S. T. Rosen, W. A. Caro, R. J. Marder, C. Zugerman, S. Rao, D. Variakojis

Research output: Contribution to journalArticlepeer-review

54 Scopus citations


A 76-year-old man developed a generalized orangered nodular eruption associated with constitutional symptoms. A biopsy specimen of a nodule revealed an extensive infiltration of histiocytes with relatively abundant cytoplasm and folded nuclei. Electron microscopy showed Langerhans' cell granules, which confirmed the diagnosis of histiocytosis X. Results of immunohistochemical studies revealed a pattern of antigen expression usually found in histiocytosis X, including la, T6, and S100. Analysis of the DNA content of the cells with flow cytometry revealed an aneuploid peak. The patient responded partially to topical mechlorethamine hydrochloride therapy.

Original languageEnglish (US)
Pages (from-to)446-450
Number of pages5
JournalArchives of Dermatology
Issue number4
StatePublished - Apr 1986

ASJC Scopus subject areas

  • Dermatology


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