Histiocytosis X: Flow Cytometric DNA-Content and Immunohistochemical and Ultrastructural Analysis

N. S. Goldberg; K. Bauer; S. T. Rosen; W. A. Caro; R. J. Marder; C. Zugerman; S. Rao; D. Variakojis

doi:10.1001/archderm.122.4.446

Histiocytosis X: Flow Cytometric DNA-Content and Immunohistochemical and Ultrastructural Analysis

N. S. Goldberg, K. Bauer, S. T. Rosen, W. A. Caro, R. J. Marder, C. Zugerman, S. Rao, D. Variakojis

Pathology

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Abstract

A 76-year-old man developed a generalized orangered nodular eruption associated with constitutional symptoms. A biopsy specimen of a nodule revealed an extensive infiltration of histiocytes with relatively abundant cytoplasm and folded nuclei. Electron microscopy showed Langerhans' cell granules, which confirmed the diagnosis of histiocytosis X. Results of immunohistochemical studies revealed a pattern of antigen expression usually found in histiocytosis X, including la, T6, and S100. Analysis of the DNA content of the cells with flow cytometry revealed an aneuploid peak. The patient responded partially to topical mechlorethamine hydrochloride therapy.

Original language	English (US)
Pages (from-to)	446-450
Number of pages	5
Journal	Archives of Dermatology
Volume	122
Issue number	4
DOIs	https://doi.org/10.1001/archderm.122.4.446
State	Published - Apr 1986

ASJC Scopus subject areas

Dermatology

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abstract = "A 76-year-old man developed a generalized orangered nodular eruption associated with constitutional symptoms. A biopsy specimen of a nodule revealed an extensive infiltration of histiocytes with relatively abundant cytoplasm and folded nuclei. Electron microscopy showed Langerhans' cell granules, which confirmed the diagnosis of histiocytosis X. Results of immunohistochemical studies revealed a pattern of antigen expression usually found in histiocytosis X, including la, T6, and S100. Analysis of the DNA content of the cells with flow cytometry revealed an aneuploid peak. The patient responded partially to topical mechlorethamine hydrochloride therapy.",

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T2 - Flow Cytometric DNA-Content and Immunohistochemical and Ultrastructural Analysis

AU - Goldberg, N. S.

AU - Bauer, K.

AU - Rosen, S. T.

AU - Caro, W. A.

AU - Marder, R. J.

AU - Zugerman, C.

AU - Rao, S.

AU - Variakojis, D.

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Histiocytosis X: Flow Cytometric DNA-Content and Immunohistochemical and Ultrastructural Analysis

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