Histologic comparison of experimental coronary artery bypass grafts: Similarity of in situ and free internal mammary artery grafts

R. C. Daly, P. M. McCarthy, T. A. Orszulak, H. V. Schaff, W. D. Edwards

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

This study compares patency and histologic structure of in situ internal mammary artery grafts, free internal mammary artery grafts, stripped, free internal mammary artery grafts, and stripped, free superficial femoral artery grafts (a muscular artery model) in a canine model or coronary artery bypass. Twenty-four adult mongrel dogs underwent bypass of the circumflex coronary artery with one of the above grafts. Three months postoperatively, graft patency was assessed by angiogram, and postmortem specimens were studied by intraluminal injection of a dilute barium solution proximal to the graft. Proximal, mid, and distal segments of each graft were examined microscopically. In situ internal mammary artery grafts and free internal mammary artery grafts were not significantly different in regard to patency, vascular wall cellular structure, or perfusion of the vasa vasorum. The stripped, free internal mammary artery group had a higher incidence of thrombosis, intimal thickening, and medial injury than the pedicled (in situ and free internal mammary artery) grafts. This difference may be due to early vascular wall ischemia as a result of poor early perfusion of the vasa vasorum. The stripped, free superficial femoral artery grafts were all patent, but all had adventitial injury.

Original languageEnglish (US)
Pages (from-to)19-29
Number of pages11
JournalJournal of Thoracic and Cardiovascular Surgery
Volume96
Issue number1
DOIs
StatePublished - 1988

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Histologic comparison of experimental coronary artery bypass grafts: Similarity of in situ and free internal mammary artery grafts'. Together they form a unique fingerprint.

Cite this