Histologic verification of leukemia, myelodysplasia, and multiple myeloma diagnoses in patients in Ukraine, 1987-1998

Irina Dyagil, Mircea Adam, Gilbert W. Beebe, J. David Burch, Svetlana N. Gaidukova, Daniel Gluzman, Natalia Gudzenko, Victor Klimenko, Lo Ann Peterson, Robert F. Reiss, Stuart C. Finch*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

In preparation for a possible large epidemiological study of radiation-related leukemia in Chernobyl clean-up workers of Ukraine, histologic evaluation of 62 cases of leukemia and related disorders was conducted by a panel of expert hematologists and hematopathologists from the United States, France, and Ukraine. All cases were randomly selected from a surrogate population of men in the general population of 6 regions of Ukraine who were between the ages of 20 and 60 years in 1986 and were reported to have developed leukemia, myelodysplasia, or multiple myeloma between the years 1987 and 1998. The hematologists and hematopathologists on the panel were in agreement with one another and with the previously reported diagnoses and classifications of about 90% of the cases of acute and chronic leukemia in the study. These results suggest that strong reliance can be placed on the clinical diagnoses of acute and chronic forms of leukemia and multiple myeloma that have occurred in Ukrainian Chernobyl clean-up workers providing that the diagnoses are supported by records of the patients having had adequate histologic bone marrow studies. The number of cases in this study with the diagnosis of myelodysplasia, however, was too small to draw firm conclusions.

Original languageEnglish (US)
Pages (from-to)55-60
Number of pages6
JournalInternational journal of hematology
Volume76
Issue number1
DOIs
StatePublished - Jul 2002

Keywords

  • Leukemia
  • Multiple myeloma
  • Myelodysplasia
  • Ukraine

ASJC Scopus subject areas

  • Hematology

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