Histological quantification of astrocytosis after cerebral infarction: A systematic review

Peter J. Ostergaard, Matthew B. Jensen*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations

Abstract

Accurate histological quantification of astrocytosis after cerebral infarction is needed as this process may affect, and be affected by, many potential restorative treatments under investigation. We performed a systematic review to determine the most reliable histological method reported for measurement of postinfarction astrocytosis. We found reports of multiple techniques to quantify various parameters of immunohistochemical staining for the astrocyte marker glial fibrillary acidic protein on photomicrographs with several software packages. We found no studies directly comparing techniques. We conclude that the reported methods seem reasonable, but the descriptions were often insufficiently detailed to allow for replication, and the lack of comparison data makes the best method unclear. Further research is needed to optimize the analysis of this important tissue outcome after cerebral infarction.

Original languageEnglish (US)
Pages (from-to)439-443
Number of pages5
JournalInternational Journal of Neuroscience
Volume123
Issue number7
DOIs
StatePublished - Jul 2013

Keywords

  • Astrocytosis
  • Glial scar
  • Histological quantification
  • Measurement
  • Stroke

ASJC Scopus subject areas

  • General Neuroscience

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