Histone 3 modifications and blood pressure in the Beijing Truck Driver Air Pollution Study

Jacob K. Kresovich, Zhou Zhang, Fang Fang, Yinan Zheng, Marco Sanchez-Guerra, Brian T. Joyce, Jia Zhong, Yana Chervona, Sheng Wang, Dou Chang, John P. McCracken, Anaite Díaz, Matteo Bonzini, Michele Carugno, Petros Koutrakis, Choong Min Kang, Shurui Bian, Tao Gao, Hyang Min Byun, Joel SchwartzAndrea A. Baccarelli, Lifang Hou*

*Corresponding author for this work

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Context: Histone modifications regulate gene expression; dysregulation has been linked with cardiovascular diseases. Associations between histone modification levels and blood pressure in humans are unclear. Objective: We examine the relationship between global histone concentrations and various markers of blood pressure. Materials and methods: Using the Beijing Truck Driver Air Pollution Study, we investigated global peripheral white blood cell histone modifications (H3K9ac, H3K9me3, H3K27me3, and H3K36me3) associations with pre- and post-work measurements of systolic (SBP) and diastolic (DBP) blood pressure, mean arterial pressure (MAP), and pulse pressure (PP) using multivariable mixed-effect models. Results: H3K9ac was negatively associated with pre-work SBP and MAP; H3K9me3 was negatively associated with pre-work SBP, DBP, and MAP; and H3K27me3 was negatively associated with pre-work SBP. Among office workers, H3K9me3 was negatively associated with pre-work SBP, DBP, and MAP. Among truck drivers, H3K9ac and H3K27me were negatively associated with pre-work SBP, and H3K27me3 was positively associated with post-work PP. Discussion and conclusion: Epigenome-wide H3K9ac, H3K9me3, and H3K27me3 were negatively associated with multiple pre-work blood pressure measures. These associations substantially changed during the day, suggesting an influence of daily activities. Blood-based histone modification biomarkers are potential candidates for studies requiring estimations of morning/pre-work blood pressure.

Original languageEnglish (US)
Pages (from-to)584-593
Number of pages10
JournalBiomarkers
Volume22
Issue number6
DOIs
StatePublished - Aug 18 2017

Keywords

  • Epigenetics
  • H3K27me3
  • H3K36me3
  • H3K9ac
  • H3K9me3
  • blood pressure
  • histone modifications

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Health, Toxicology and Mutagenesis

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    Kresovich, J. K., Zhang, Z., Fang, F., Zheng, Y., Sanchez-Guerra, M., Joyce, B. T., Zhong, J., Chervona, Y., Wang, S., Chang, D., McCracken, J. P., Díaz, A., Bonzini, M., Carugno, M., Koutrakis, P., Kang, C. M., Bian, S., Gao, T., Byun, H. M., ... Hou, L. (2017). Histone 3 modifications and blood pressure in the Beijing Truck Driver Air Pollution Study. Biomarkers, 22(6), 584-593. https://doi.org/10.1080/1354750X.2017.1347961