Histone cleavage as a mechanism for epigenetic regulation: Current insights and perspectives

P. Zhou, E. Wu, H. B. Alam, Y. Li*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Discovered over a century ago, histones constitute one of the oldest families of proteins and have been remarkably conserved throughout eukaryotic evolution. However, only for the past 30 years have histones demonstrated that their influence extends far beyond packaging DNA. To create the various chromatin structures that are necessary for DNA function in higher eukaryotes, histones undergo post-translational modifications. While many such modifications are well documented, others, such as histone tail cleavage are less understood. Recent studies have discovered several proteases that cleave histones and have suggested roles for clipped histones in stem cell differentiation and aging in addition to infection and inflammation; the underlying mechanisms, however, are uncertain. One histone class in particular, histone H3, has received outstanding interest due to its numerous N-terminal modification sites and prevalence in regulating homeostatic processes. Here, with special consideration of H3, we will discuss the novel findings regarding histone proteolytic cleavage as well as their significance in the studies of immunology and epigenetics.

Original languageEnglish (US)
Pages (from-to)1164-1172
Number of pages9
JournalCurrent Molecular Medicine
Volume14
Issue number9
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Keywords

  • Cleavage
  • H3
  • Histone
  • Post-translational modification

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology

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