Histone deacetylase inhibitor and demethylating agent chromatin compaction and the radiation response by cancer cells

Gil Bar-Sela, Kristi Muldoon Jacobs, David Gius*

*Corresponding author for this work

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

It now appears that epigenetics plays a central role in transformation, both in vitro and in vivo. The expression and regulation of DNA methylation and the subsequent chromatin structure are significantly altered in tumor cells, suggesting a direct role in the process of in vivo cellular transformation. If epigenetics and posttranslational modifications of histones play a role in transformation, then it seems logical that the genes regulating chromatin compaction may also be molecular targets and markers in profiling tumor cell resistance. Local remodeling of chromatin is a key step in the regulation of gene expression, and altering the expression of these genes might also favorably alter how tumor cells respond to anticancer agents. Several new agents that alter chromatin compaction, either methyltransferase or histone deacetylases inhibitors, are progressing through clinical trials and have shown promising preclinical interactions when combined with radiation. In this review, we discuss the potential for histone deacetylases inhibitors as radiosensitizing agents.

Original languageEnglish (US)
Pages (from-to)65-69
Number of pages5
JournalCancer Journal
Volume13
Issue number1
DOIs
StatePublished - Jan 1 2007

Keywords

  • Chromatin
  • Epigenetic
  • Histone deacetylases
  • Methylation
  • Radiation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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