Histone deacetylase inhibitors: A novel strategy for neuroprotection and cardioprotection following ischemia/ reperfusion injury

Zachary Pickell, Aaron M. Williams, Hasan B. Alam, Cindy H. Hsu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Ischemia/reperfusion injury is a complex molecular cascade that causes deleterious cellular damage and organ dysfunction. Stroke, sudden cardiac arrest, and acute myocardial infarction are the most common causes of ischemia/rep-erfusion injury without effective pharmacologic therapies. Existing preclinical evidence suggests that histone deacetylase inhibitors may be an efficacious, affordable, and clinically feasible therapy that can improve neurologic and cardiac outcomes following ischemia/reperfusion injury. In this review, we discuss the pathophysiology and epigenetic modulations of ischemia/ reperfusion injury and focus on the neuroprotective and cardioprotective effects of histone deacetylase inhibitors. We also summarize the protective effects of histone deacetylase inhibitors for other vital organs and highlight the key research priorities for their successful translation to the bedside.

Original languageEnglish (US)
Article numbere016349
JournalJournal of the American Heart Association
Volume9
Issue number11
DOIs
StatePublished - Jun 2 2020

Keywords

  • Cardiac arrest
  • Epigenetics
  • Histone deacetylase inhibitors
  • Myocardial infarction
  • Stroke

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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