Histone deacetylase sirtuin 1 deacetylates IRF1 protein and programs dendritic cells to control Th17 protein differentiation during autoimmune inflammation

Heeyoung Yang; Sang Myeong Lee; Beixue Gao; Jinping Zhang; Deyu Fang

doi:10.1074/jbc.M113.527531

Histone deacetylase sirtuin 1 deacetylates IRF1 protein and programs dendritic cells to control Th17 protein differentiation during autoimmune inflammation

Heeyoung Yang, Sang Myeong Lee, Beixue Gao, Jinping Zhang, Deyu Fang^*

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

Background: The roles of Sirt1 in regulating dendritic functions are not known. Results: Sirt1 deacetylates the IRF1 transcription factor to suppress IL-27 expression in dendritic cells, leading to elevated Th17 differentiation for inflammatory disease development. Conclusion: Sirt1 programs DC functions to promote Th17 differentiation and inflammation. Significance: This study defines a previously unappreciated inflammatory role of Sirt1 in dendritic cells.

Original language	English (US)
Pages (from-to)	37256-37266
Number of pages	11
Journal	Journal of Biological Chemistry
Volume	288
Issue number	52
DOIs	https://doi.org/10.1074/jbc.M113.527531
State	Published - Dec 27 2013

ASJC Scopus subject areas

Molecular Biology
Biochemistry
Cell Biology

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10.1074/jbc.M113.527531

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title = "Histone deacetylase sirtuin 1 deacetylates IRF1 protein and programs dendritic cells to control Th17 protein differentiation during autoimmune inflammation",

abstract = "Background: The roles of Sirt1 in regulating dendritic functions are not known. Results: Sirt1 deacetylates the IRF1 transcription factor to suppress IL-27 expression in dendritic cells, leading to elevated Th17 differentiation for inflammatory disease development. Conclusion: Sirt1 programs DC functions to promote Th17 differentiation and inflammation. Significance: This study defines a previously unappreciated inflammatory role of Sirt1 in dendritic cells.",

author = "Heeyoung Yang and Lee, {Sang Myeong} and Beixue Gao and Jinping Zhang and Deyu Fang",

year = "2013",

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T1 - Histone deacetylase sirtuin 1 deacetylates IRF1 protein and programs dendritic cells to control Th17 protein differentiation during autoimmune inflammation

AU - Yang, Heeyoung

AU - Lee, Sang Myeong

AU - Gao, Beixue

AU - Zhang, Jinping

AU - Fang, Deyu

PY - 2013/12/27

Y1 - 2013/12/27

N2 - Background: The roles of Sirt1 in regulating dendritic functions are not known. Results: Sirt1 deacetylates the IRF1 transcription factor to suppress IL-27 expression in dendritic cells, leading to elevated Th17 differentiation for inflammatory disease development. Conclusion: Sirt1 programs DC functions to promote Th17 differentiation and inflammation. Significance: This study defines a previously unappreciated inflammatory role of Sirt1 in dendritic cells.

AB - Background: The roles of Sirt1 in regulating dendritic functions are not known. Results: Sirt1 deacetylates the IRF1 transcription factor to suppress IL-27 expression in dendritic cells, leading to elevated Th17 differentiation for inflammatory disease development. Conclusion: Sirt1 programs DC functions to promote Th17 differentiation and inflammation. Significance: This study defines a previously unappreciated inflammatory role of Sirt1 in dendritic cells.

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Histone deacetylase sirtuin 1 deacetylates IRF1 protein and programs dendritic cells to control Th17 protein differentiation during autoimmune inflammation

Abstract

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