Histone deacetylase sirtuin 1 deacetylates IRF1 protein and programs dendritic cells to control Th17 protein differentiation during autoimmune inflammation

Heeyoung Yang, Sang Myeong Lee, Beixue Gao, Jinping Zhang, Deyu Fang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

Background: The roles of Sirt1 in regulating dendritic functions are not known. Results: Sirt1 deacetylates the IRF1 transcription factor to suppress IL-27 expression in dendritic cells, leading to elevated Th17 differentiation for inflammatory disease development. Conclusion: Sirt1 programs DC functions to promote Th17 differentiation and inflammation. Significance: This study defines a previously unappreciated inflammatory role of Sirt1 in dendritic cells.

Original languageEnglish (US)
Pages (from-to)37256-37266
Number of pages11
JournalJournal of Biological Chemistry
Volume288
Issue number52
DOIs
StatePublished - Dec 27 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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