Histone deacetylases as transcriptional activators? Role reversal in inducible gene regulation.

Inna Nusinzon*, Curt M. Horvath

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

73 Scopus citations

Abstract

Histone deacetylation enzymes have often been associated with the suppression of eukaryotic gene transcription. In contrast, recent studies of inducible gene regulation indicate that protein deacetylation can also be required as a transcriptional activation signal. The concept of protein deacetylation as a requirement for transcription activation seems to contradict earlier conclusions about the function of deacetylation in gene suppression. However, in the context of a more global interpretation, these opposing effects of deacetylation imply its dynamic role in the overall control of gene expression. The exact requirement for deacetylation differs among promoters, depending on their specific architecture and regulation scenario.

Original languageEnglish (US)
Pages (from-to)re11
JournalScience's STKE : signal transduction knowledge environment
Volume2005
Issue number296
DOIs
StatePublished - Aug 9 2005

ASJC Scopus subject areas

  • Medicine(all)

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