TY - JOUR
T1 - Histone deacetylases as transcriptional activators? Role reversal in inducible gene regulation.
AU - Nusinzon, Inna
AU - Horvath, Curt M.
PY - 2005/8/9
Y1 - 2005/8/9
N2 - Histone deacetylation enzymes have often been associated with the suppression of eukaryotic gene transcription. In contrast, recent studies of inducible gene regulation indicate that protein deacetylation can also be required as a transcriptional activation signal. The concept of protein deacetylation as a requirement for transcription activation seems to contradict earlier conclusions about the function of deacetylation in gene suppression. However, in the context of a more global interpretation, these opposing effects of deacetylation imply its dynamic role in the overall control of gene expression. The exact requirement for deacetylation differs among promoters, depending on their specific architecture and regulation scenario.
AB - Histone deacetylation enzymes have often been associated with the suppression of eukaryotic gene transcription. In contrast, recent studies of inducible gene regulation indicate that protein deacetylation can also be required as a transcriptional activation signal. The concept of protein deacetylation as a requirement for transcription activation seems to contradict earlier conclusions about the function of deacetylation in gene suppression. However, in the context of a more global interpretation, these opposing effects of deacetylation imply its dynamic role in the overall control of gene expression. The exact requirement for deacetylation differs among promoters, depending on their specific architecture and regulation scenario.
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U2 - 10.1126/stke.2962005re11
DO - 10.1126/stke.2962005re11
M3 - Review article
C2 - 16091625
AN - SCOPUS:30944470262
SN - 1937-9145
VL - 2005
SP - re11
JO - Science's STKE : signal transduction knowledge environment
JF - Science's STKE : signal transduction knowledge environment
IS - 296
ER -