Histone H3 lysine 4 (H3K4) methylation in development and differentiation

Joel C. Eissenberg; Ali Shilatifard

doi:10.1016/j.ydbio.2009.08.017

Histone H3 lysine 4 (H3K4) methylation in development and differentiation

Joel C. Eissenberg^*, Ali Shilatifard

^*Corresponding author for this work

Biochemistry and Molecular Genetics

Research output: Contribution to journal › Review article › peer-review

239 Scopus citations

Abstract

Covalent modification of histones on chromatin is a dynamic mechanism by which various nuclear processes are regulated. Methylation of histone H3 on lysine 4 (H3K4) implemented by the macromolecular complex COMPASS and its related complexes is associated with transcriptionally active regions of chromatin. Enzymes that catalyze H3K4 methylation were initially characterized genetically as regulators of Hox loci, long before their catalytic functions were recognized. Since their discovery, genetic and biochemical studies of H3K4 methylases and demethylases have provided important mechanistic insight into the role of H3K4 methylation in HOX gene regulation during development.

Original language	English (US)
Pages (from-to)	240-249
Number of pages	10
Journal	Developmental Biology
Volume	339
Issue number	2
DOIs	https://doi.org/10.1016/j.ydbio.2009.08.017
State	Published - Mar 15 2010

Keywords

Compass complex
HOX genes
Histone methylation
MLL
SET domain
Trithorax

ASJC Scopus subject areas

Molecular Biology
Developmental Biology
Cell Biology

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10.1016/j.ydbio.2009.08.017

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title = "Histone H3 lysine 4 (H3K4) methylation in development and differentiation",

abstract = "Covalent modification of histones on chromatin is a dynamic mechanism by which various nuclear processes are regulated. Methylation of histone H3 on lysine 4 (H3K4) implemented by the macromolecular complex COMPASS and its related complexes is associated with transcriptionally active regions of chromatin. Enzymes that catalyze H3K4 methylation were initially characterized genetically as regulators of Hox loci, long before their catalytic functions were recognized. Since their discovery, genetic and biochemical studies of H3K4 methylases and demethylases have provided important mechanistic insight into the role of H3K4 methylation in HOX gene regulation during development.",

keywords = "Compass complex, HOX genes, Histone methylation, MLL, SET domain, Trithorax",

author = "Eissenberg, {Joel C.} and Ali Shilatifard",

note = "Funding Information: We thank Dr. Edwin Smith for helpful comments on the manuscript and Dr. Zoya Avramova for helpful discussion on Arabidopsis COMPASS. We thank Dr. Philip Ingham and the International Journal of Developmental Biology for permission to use the image shown in Fig. 1 B. The work in authors' laboratories is supported by NSF grant MCB 0724501 to JCE and NIH R01CA89455, R01GM069905 to A.S.",

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doi = "10.1016/j.ydbio.2009.08.017",

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AU - Eissenberg, Joel C.

AU - Shilatifard, Ali

N1 - Funding Information: We thank Dr. Edwin Smith for helpful comments on the manuscript and Dr. Zoya Avramova for helpful discussion on Arabidopsis COMPASS. We thank Dr. Philip Ingham and the International Journal of Developmental Biology for permission to use the image shown in Fig. 1 B. The work in authors' laboratories is supported by NSF grant MCB 0724501 to JCE and NIH R01CA89455, R01GM069905 to A.S.

PY - 2010/3/15

Y1 - 2010/3/15

N2 - Covalent modification of histones on chromatin is a dynamic mechanism by which various nuclear processes are regulated. Methylation of histone H3 on lysine 4 (H3K4) implemented by the macromolecular complex COMPASS and its related complexes is associated with transcriptionally active regions of chromatin. Enzymes that catalyze H3K4 methylation were initially characterized genetically as regulators of Hox loci, long before their catalytic functions were recognized. Since their discovery, genetic and biochemical studies of H3K4 methylases and demethylases have provided important mechanistic insight into the role of H3K4 methylation in HOX gene regulation during development.

AB - Covalent modification of histones on chromatin is a dynamic mechanism by which various nuclear processes are regulated. Methylation of histone H3 on lysine 4 (H3K4) implemented by the macromolecular complex COMPASS and its related complexes is associated with transcriptionally active regions of chromatin. Enzymes that catalyze H3K4 methylation were initially characterized genetically as regulators of Hox loci, long before their catalytic functions were recognized. Since their discovery, genetic and biochemical studies of H3K4 methylases and demethylases have provided important mechanistic insight into the role of H3K4 methylation in HOX gene regulation during development.

KW - Compass complex

KW - HOX genes

KW - Histone methylation

KW - MLL

KW - SET domain

KW - Trithorax

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DO - 10.1016/j.ydbio.2009.08.017

M3 - Review article

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SN - 0012-1606

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EP - 249

JO - Developmental Biology

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ER -

Histone H3 lysine 4 (H3K4) methylation in development and differentiation

Abstract

Keywords

ASJC Scopus subject areas

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