Histopathologic findings characteristic of CARD14-associated papulosquamous eruption

Nan G. Ring*, Brittany G. Craiglow, Gauri Panse, Richard J. Antaya, Kurt Ashack, Richard Ashack, Esteban F. Faith, Amy S. Paller, Jennifer M. McNiff, Keith A. Choate, Christine J. Ko

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Background: Pathogenic mutations in caspase recruitment domain-containing protein 14 (CARD14) lead to CARD14-associated papulosquamous eruption, which shares clinicopathologic findings with psoriasis and pityriasis rubra pilaris. We aimed to describe distinguishing histopathologic features of CARD14-associated papulosquamous eruption. Methods: This retrospective study examined the histopathologic features of specimens from patients with confirmed CARD14-associated papulosquamous eruption and adult patients with plaque psoriasis and pityriasis rubra pilaris. Results: Lesional skin biopsies from patients with CARD14-associated papulosquamous eruption consistently showed alternating checkerboard parakeratosis and orthokeratosis, acanthosis without acantholysis, and dilated vessels in the dermal papillae, with some cases also showing follicular plugging. Conclusion: CARD14-associated papulosquamous eruption has a range of findings, with a predominance of features typically associated with pityriasis rubra pilaris.

Original languageEnglish (US)
JournalJournal of cutaneous pathology
DOIs
StateAccepted/In press - Jan 1 2019

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Keywords

  • CARD14
  • papulosquamous
  • pityriasis rubra pilaris
  • psoriasis
  • PSORS2

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Dermatology

Cite this

Ring, N. G., Craiglow, B. G., Panse, G., Antaya, R. J., Ashack, K., Ashack, R., Faith, E. F., Paller, A. S., McNiff, J. M., Choate, K. A., & Ko, C. J. (Accepted/In press). Histopathologic findings characteristic of CARD14-associated papulosquamous eruption. Journal of cutaneous pathology. https://doi.org/10.1111/cup.13633